| Post Name | Assistant Professor in Biochemistry - Medical Education |
|---|---|
| Question Paper Code | 062/2022/OL |
| Category Code | 004/2021 |
| Date of Test | 11 August 2022 |
| Exam Type | Online Examination |
| Total Questions | 100 |
1
Which of the following statements is/are correct about RAST? (i) It measures IgE antibodies in the serum (ii) It is scored from 0 to 6 (iii) It is the same as the skin prick test
Answer
B. Only (i) and (ii)
2
A solution with pH 4 is _____________ times more acidic than a solution with pH 6
Answer
D. 100
3
Which of the following drugs is not an enzyme inhibitor?
Answer
C. siRNA
4
Identify the protein that matches with the following descriptions: (i) Fibrous protein (ii) Composed of three chains (iii) Associated with Ehlers-Danlos Syndrome
Answer
A. Collagen
5
Enzyme activity is measured based on the intensity of emitted light in _________ method
Answer
C. Luminiscence
6
Pick the group of non-polar aminoacids
Answer
D. Alanine, Leucine, Isoleucine, Methionine
7
Which of he following serves the purpose of locating the radioactive emissions in the process of autoradiography?
Answer
B. Photographic Emulsion
8
Which organelle does not contain nucleic acid?
Answer
C. Golgi Body
9
The plasma protein that is involved in copper homeostasis is ________
Answer
Question Cancelled
10
Which technique/s can be used for the analysis of nucleic acids? (i) PAGE (ii) Northern Blotting (iii) SDS PAGE (iv) Southern Blotting
Answer
D. Only (i), (ii) and (iv)
11
Identify the class of antibody with the bighest avidity for antigens:
Answer
B. IgM
12
A buffer solution contain 0.36 M sodium acetate (CH3COONa) and 0.036 M acetic acid (CH3COOH),pKa=4.8. What is the pH of this buffer solution?
Answer
C. 5.8
13
Which kind of shift is associated with uv absorption of DNA that is denatured?
Answer
C. Hyperchromic shift
14
Match the following correctly: (i) Oxidoreductase (a) Fumarase (ii) Hydrolase (b) Aminoacyl tRNA Synthase (iii) Lyase (c) Urease (iv) Ligase (d) Catalase
Answer
B. (i)-(d), (ii)-(c), (iii)-(a), (iv)-(b)
15
The aminoacid that cannot be found in alpha-helix structure of proteins is _________
Answer
Question Cancelled
16
Which term represents the number of substrate molecules that can be converted to product by a single enzyme molecule per unit time?
Answer
D. Turnover number
17
Which of the following is used to bombard the sample in Mass spectrometry?
Answer
C. Electrons
18
The proteins bound to ion exchange resins can be displaced by altering the ____________
Answer
B. Ionic strength of eluent buffer
19
Pick the incorrect statement
Answer
D. NADH dehydrogenase is an extrinsic protein
20
Which of the following diseases is associated with an elevated value of serum Creatine kinase-3 (CK3)?
Answer
D. Muscular Dystrophy
21
Serum free fatty acids are found in combination with _________
Answer
C. Albumin
22
All N-linked oligosaccharides have _______
Answer
A. Pentasaccharide core
23
Hemoglobin containing two mutant β-globin chain (Hbsβ) moves slowly towards anode during electrophoresis is due to the presence of ____________
Answer
C. Valine
24
All the monosaccharides contain one or more chiral carbon atoms except
Answer
A. Dihydroxyacetone
25
Lipids have ____ specific gravities than water
Answer
B. Less
26
Chemical name of Guanine is
Answer
A. 2-amino, 6-oxypurine
27
Number of base pairs per one complete turn of DNA double helix are:
Answer
B. 10
28
A drug _____ inhibits protein synthesis in both prokaryotes and eukaryotes
Answer
C. Puromycin
29
Prokaryotic transcription start regions are called as
Answer
C. Promoters
30
Pribnow-Schaller box has a sequence of _________
Answer
A. TATAAT
31
The Hypothesis is used to make _____
Answer
Question Cancelled
32
Non-probability is also known as ________
Answer
D. Deliberate sampling
33
Precision is the closeness of a ________
Answer
A. repeated measurements
34
The expression of probability density function whose values range from zero to positive infinity is _______
Answer
A. Chi-square distribution
35
𝑋 with n-1 degrees of freedom equivalent to __________ 2
Answer
A. (n-1) 𝑠 𝜎2 2
36
Coefficient of variation is the measure of ratio of _____ stated as a percentage
Answer
D. standard deviation to the mean
37
The term "biological reference interval" that deemed normal for a healthy person approved by _________
Answer
B. ISO 15189
38
Reference value of serum creatinine in adult male would be ____________
Answer
Question Cancelled
39
F test result is obtained by calculating the _____
Answer
D. Between treatment mean square divided by residual mean square
40
The nonparametric method used to compare a single sample with some hypothesized value is ______________
Answer
D. A sign test
41
Which of the following statements regarding Basal Metabolic Rate is incorrect?
Answer
C. It is the minimum amount of energy required to sustain vital functions during sleep
42
Which of the following is an appetite suppressant?
Answer
B. Serotonin
43
Select the false statement regarding Carcino Embryonic Antigen
Answer
B. Useful for diagnosing localized breast cancer
44
Which of the following is an oncosuppresser gene?
Answer
D. p21
45
Which of the following vitamin do not have specific role in bone formation?
Answer
A. Pyridoxal phosphate
46
All the following are anti-vitamins except
Answer
B. Tyramine
47
The toxin responsible for Epidemic dropsy is
Answer
D. Sanguinarine
48
Which mineral deficiency is characterized by both hematological and neurological manifestations?
Answer
B. Copper
49
Tetany is seen in
Answer
C. Metabolic alkalosis
50
Which of the following enzyme do NOT require biotin for its action?
Answer
A. Aminoimidazole ribonucleotide carboxylase
51
Select the technique that is used for studying gene expression in a tissue
Answer
C. Microarray technique
52
Which of the following statement is false regarding innate immunity?
Answer
B. Lymphocytes play a major role
53
The autoimmune disease where tissue destruction is mediated directly by T cells is
Answer
Question Cancelled
54
Maternal serum Alpha feto protein level is decreased in
Answer
B. Down syndrome
55
Which of the following is an RNA directed site specific nuclease?
Answer
A. CRISPER-Cas9
56
Which of the following is a sulfur containing vitamin?
Answer
A. Thiamine
57
All the following features are true regarding kwashiorkor EXCEPT
Answer
Question Cancelled
58
Which of the following vector carries the risk of insertional mutagenesis when used in gene therapy?
Answer
A. Retroviruses
59
Simultaneous analysis of multiple metabolites in the same blood spot is referred to as
Answer
Question Cancelled
60
The test that is done to assess vitamin B12 absorption is
Answer
C. Schilling test
61
Aspirin is used in the treatment of myocardial infarction since it inhibits platelet aggregation by inhibiting the synthesis of
Answer
B. Thromboxane
62
Refsum disease characterized by vision loss, anosmia ataxia and polyneuropathy is due to defect in
Answer
A. Fatty acid oxidation
63
The assay of 5 Hydroxy indole acetic acid in urine is useful in the diagnosis of
Answer
C. Carcinoid syndrome
64
Pellagra like symptoms is commonly seen in disorders associated with the defect in the metabolism of
Answer
D. Tryptophan
65
The rate limiting enzymes of gluconeogenesis are (i) Pyruvate carboxylase (ii) Pyruvate dehydrogenase (iii) Glucose-6-phosphatase (iv) Phosphofructokinase
Answer
C. (i) and (iii)
66
The type of porphyria associated with the defect in the enzyme uroporphyrinogen decarboxylase is
Answer
A. Porphyria cutanea tarda
67
Ochronosis, a condition where black pigments are deposited in cartilage is due to deficiency of the enzyme
Answer
B. Homogentisic acid oxidase
68
All of the following are types of type II detoxification reactions except
Answer
A. Oxidation
69
Which of the following is not a diagnostic-criteria for a metabolic syndrome?
Answer
C. HDL-cholesterol - more than 50 mg/dl
70
The liver function test parameters for a patient admitted with jaundice is as follows serum total bilirubin - 10 mg/dl, Direct bilirubin - 9.5 mg/dl. Urine: Bile salts and bile pigments - positive which of the following enzymes is increased in this patient?
Answer
B. Alkaline phosphatase
71
Urea reduction ration is used to
Answer
A. Assess the adequacy of hemodialysis
72
The lab data of a patient's serum sample were as follows: Total Cholesterol: 300 mg/dL, HDL cholesterol: 40 mg/dl and Triglycerides : 200 mg/dL The calculated LDL cholesterol level for the patient is
Answer
C. 220 mg/dL
73
All of the following enzymes are involved in substrate level phosphorylation except
Answer
D. Phosphoenolpyruvate carboxykinase
74
Regan isoenzymes is increased in
Answer
A. Carcinoma of lung
75
Ezetimibe reduces blood cholesterol levels by
Answer
B. Inhibiting absorption
76
Fatty liver can be prevented by
Answer
A. Methionine
77
Which of the following statement in NOT TRUE about Levey-Jennings chart?
Answer
Question Cancelled
78
All of the following are types of preanalyltical variables except
Answer
D. Water quality
79
Triple test, commonly used in maternal screening in second trimester include all of the following markers except
Answer
C. Progesterone
80
Flipped pattern of Lactate dehydrogenase isoenzyme is seen in
Answer
A. Myocardial infarction
81
For Covid 19 RT-PCR test mineral used in RTPCR process
Answer
B. Mg
82
The VLDL, LD: levels increase in blood due to high intake of
Answer
B. Fructose diet
83
The elementary composition of the human body (dry weight basis) in %
Answer
Question Cancelled
84
Normal chemical composition for a man weighting 65 kg
Answer
D. None
85
A 54-year male presents with acute abdominal pain, no skin photosensitization, large amount of aminolevulinic acid (ALA) and porphobilinogen (PBG) in urine, and symptoms exacerbated by steroids and several other drugs. Which of the following best describes the conditions?
Answer
B. Acute intermittent porphyria
86
A 10-year old boy develops sever diarrhoea while travelling to India. the laboratory blood investigation shows arterial blood pH 7.25; partial pressure of carbon dioxide 24 mm Hg; bicarbinate 10 mEq/L and normal anion gap. Which of the following is correct diagnosis?
Answer
A. Metabolic acidosis
87
A 40-year old woman presented with history of fatigue, easy bruising, bleeding from gums while brushing her teeth and a diffuse rash involving her extremities and trunk that had been present for several days. The deficiency of which of the following is because of her symptoms?
Answer
D. Ascorbic acid
88
A 29-year old man comes to his doctor with symptoms of HIV infection. The doctor orders several confirmatory tests, for one of them a protein sample is taken and is run on electrophoretic gel, causing it to separate by size and charge. The protein was then transferred to a membrane, and labelled antibody is added to allow visualization of this protein. Which of the following tests in described here?
Answer
B. Western blot
89
In cancer patients who have been continuously receiving methotrexate, the target cells of tumor with time become sensitive to his drug. In this case, most commonly gene amplification of the following enzyme is observed:
Answer
A. Dihydrofolate reductase
90
A doctor administered allopurinol to a 26-year old young man with symptoms of gout. Which of the following pharmacological action of allopurinol ensures therapeutic effect?
Answer
A. Inhibiting uric acid synthesis
91
A 56-year old man was operated on prostate cancer, three months later he underwent a course of radiotherapy and chemotherapy. .The complex of medicinal preparations prescribed to the patient included 5-fluoro-deoxyuridine, which is a thymidylate synthase inhibitor, Which of the following biomolecule's synthesis is blocked by the drug?
Answer
A. DNA
92
A patient with radiation therapy because of brain tumor was prescribed vitamin E and a micro element with antioxidant function. Which of the following can be used for this purpose?
Answer
B. Selenium
93
A 3-year old child comes to the hospital with history of biting his lips and fingers, involuntary movements of upper limb and mental retardation. he has a younger healthy sister. Lab investigations showed high serum uric acid. Which of the following is the most likely diagnosis?
Answer
B. LeschNyhah Syndrome
94
A 7-year boy comes to the hospital with yellow discoloration of eyes, decreased apetite and general malaise for last 1 week. She has been passing dark colored urine and high colored faces for the same duration. Lab investigations showed serum total bilirubin 4.5 mg%, direct bilirubin 1.2 mg%, indirect faeces 3.3 mg%. liver enzymes are normal. Which of the following is the most likely cause of jaundiced in this patient?
Answer
Question Cancelled
95
A 20-year old male visits dermatology OPD with complaints of increased sensitivity to sunlight causing blistering and crusting of skin only few minutes of sun exposure. Delayed growth and intellectual disability were noticed. Skin biopsy was taken. Which of the following is the most likely diagnosis?
Answer
A. Xeroderma pigmentosum
96
a 20-year old male patient presented with severe abdominal pain with difficulty in fine motor tasks. Lab investigation showed elevated liver enzymes and increased urinary calcium and phosphate Opthalamological examination revealed Kayser Fleischer ring in the cornea. Which of the following is most likely cause of the presenting symptoms in this case?
Answer
B. Copper excess
97
A patient is undergoing radiation therapy because of breast cancer. This resulted in increased lipid peroxidation processes. In the course of which active forms of oxygen including superoxide anion radical are formed in the human body. Which of the following enzymes inactivates this anion?
Answer
A. Superoxide dismutase
98
The Anfinsen's dogma states that
Answer
B. Primary structure directs in vivo folding
99
The maximum buffering capacity occurs at
Answer
A. ±1 pH unit on either side of pKa
100
The defective DNA base excision repair (BER) is found in
Answer
C. Mutyh-associated polyposis (MAP)
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