| Post Name | Assistant Professor in Medical Oncology |
|---|---|
| Department | Medical Education |
| Question Paper Code | 101/2026/OL |
| Category Code | 799/2025 |
| Date of Test | 19 May 2026 |
| Exam Type | Online Examination |
| Total Questions | 100 |
1
Sacituzumab govitecan is an antibody-drug conjugate which uses following cytotoxic payload for its mechanism of action
Answer
B. SN 38
2
Polatuzumab vedotin is used for treatment of
Answer
A. Refractory DLBCL
3
All the following DNMT Inhibitors except
Answer
D. Tazemetostat
4
Carļ¬lzomib refers to which of the following drug class
Answer
C. Peptide epoxyketone
5
Elacestrant is an
Answer
A. Oral SERD
6
Paraneoplastic Anti CAR Antibody is associated with which of following malignancy ?
Answer
C. Melanoma
7
Genetic association with HNSCC (Head and neck squamous cell carcinoma) exists with all the following except
Answer
D. None of the above
8
Which of the following CART T cell is used in adult patients with relapsed or refractory MCL
Answer
B. Brexucabtagene autoleucel
9
All are humanized antibody except
Answer
C. Margetuximab
10
Copanlisib is a
Answer
A. PI3K inhibitor
11
Total number of persons with a history of cancer at some speciļ¬ed time point in a deļ¬ned geographic area, regardless of whether they are on remission, treatment, or cured is the deļ¬nition of
Answer
B. Prevalant cases
12
The ratio of observed survivors (all causes of death) in a cohort of cancer patients to the proportion of expected survivors in a comparable cohort of cancer free individuals.
Answer
A. Relative survival
13
Having stopped smoking within the recent past, typically for a period of 1week to 1 year is called
Answer
B. Recent smoker
14
Varenicline acts by
Answer
C. Dopaminergic reward and partial nicotinic receptor antagonist
15
Which of the following trial examine the impact of exercise and diet (emphasizing fat reduction and increased fruit and vegetable consumption) onprogression-free survival among 1,070 patients with advanced ovarian cancer ?
Answer
C. LIVES trial
16
Indications that Warrant Genetic Counseling for Hereditary Cancer Syndromes includes all except
Answer
D. Follicular carcinoma thyroid
17
Most common valvular disorder associated with mediastinal radiation is
Answer
B. Aortic valve
18
Average probability that an individual will develop or die from cancer with in a given age range or period, assuming the absence of competing causes of death is called as
Answer
D. cumulative risk
19
Cancers associated with obesity are all except
Answer
D. Synovial sarcoma
20
All are Interventional studies testing the impact of dietary change, in cancer except
Answer
B. CHALLENGE study
21
Asplenic patients are at risk for developing infection with all except
Answer
D. Staphylococous
22
Agents with activity against MRSA and VRE include all except
Answer
D. Teicoplanin
23
Classic cardiac toxicity of cyclophosphamide (CTX) is
Answer
A. acute myopericarditis
24
Human Immunodeļ¬ciency Virus (HIV)-Associated Lymphoma are all except
Answer
D. Anaplastic large cell lymphoma
25
All are risk factors for carcinoma male breast except
Answer
A. gynecomastia
26
Which of the following is at increased of Mediastinal Germ cell tumor ?
Answer
D. Kleinfelter syndrome
27
Which among the following is not related to hereditary renal cell carcinoma ?
Answer
D. Alagille syndrome
28
AII are haematological paraneoplastic manifestations of carcinoma lung except
Answer
D. Erythrocytosis
29
Radiation pneumonitis typically occurs
Answer
B. 1-6 months
30
Which of the following risk factor is associated with a denocarcinoma of oesophagus ?
Answer
B. Obesity
31
Prophylactic surgery is indicated in all the following except
Answer
D. Attenuated familial adenomatous polyposis with low polyp burden
32
What is the common and serious complication of treatment with high dose lnterleukin2 ?
Answer
B. Capillary leak syndrome
33
Mitotic index is determined by the formula
Answer
C. (Total cells in mitosis / Total number of tumor cells) Ć 100
34
Sentinel Lymph Node Biopsy (SLNB) is usually done in all the following scenarios, except
Answer
C. Inļ¬ammatory breast cancer
35
Which of the following best describes Gompertzian growth curve in the context of tumor growth ?
Answer
C. It is an S shaped (Sigmoid ) curve where the growth rate decreases exponentially over time when the population approaches maximum size.
36
According to the International Commission on Radiation Units and Measurements (ICRU) report 50/62, which of the following best describes the Gross Tumor Volume (GTV) ?
Answer
B. All gross disease including involved regional lymph nodes, and is determined by physical examination and imaging.
37
Which one of the following drugs is commonly used as a radiation sensitizer,particularly in the treatment of head and neck and cervical cancers, by inhibiting DNA repair and increasing the eļ¬ect of radiation ?
Answer
A. Cisplatin
38
Which altered fractionation schedule aims to decrease the total overall treatment time to prevent tumor proliferation ?
Answer
B. Accelerated fractionation
39
In iRECIST, what is the required action when new lesion(s) or increased tumor burden is observed following immunotherapy ?
Answer
C. Label it as "Unconļ¬rmed Progressive Disease" (iUPD) and conļ¬rm with a follow-up scan 4-8 weeks later.
40
Hormone treatment is used in all the following malignancies, except
Answer
D. Small cell lung cancer.
41
Which one of the statements is NOT true about Crizotinib.
Answer
C. Commonest adverse eļ¬ect is neutropenia
42
Diļ¬erentiation syndrome is a known complication of all the following drugs except
Answer
B. Acalabrutinib
43
FDA approved indications for CAR T-cell therapy includes all the following except
Answer
D. Burkitt lymphoma
44
The following statements about HPV vaccination are true except
Answer
D. HPV vaccine is contraindicated in immunocompromised individuals.
45
HPV vaccination has protective eļ¬ect on the following malignancies except
Answer
B. Nasopharyngeal cancer
46
Which one of the following statements is not true about Venetoclax ?
Answer
D. Venetoclax should be administered on an empty stomach
47
The following statements about Tumor Inļ¬ltrating Lymphocyte (TIL) therapy are true except
Answer
B. Tumor inļ¬ltrating lymphocytes are genetically engineered before infusion
48
The following statements about tarlatamab are true except
Answer
D. Cytopenia is not a common complication
49
Which of the following drugs is contraindicated in Charcot Marie Tooth Disease
Answer
B. Vincristine
50
Which one of the following is not a common complication of Trastuzumab based treatment
Answer
C. Interstitial nephritis
51
Which of the following statements about smoking and lungcancer association is false ?
Answer
D. The tobacco in Pipes and cigars is less harmful than the tobacco in cigarette.
52
Which of the following cancers is not associated with smoking ?
Answer
D. Testicular cancer
53
Which of the following is the correct order of the relative risk, of malignancy associated with obesity ?
Answer
A. Endometrial carcinoma > Esophageal adenocarcinoma > Gastric carcinoma
54
Which of the following statements is wrong ?
Answer
B. In the SUCCESS-C trial weight loss intervention in stage II-III breast cancer signiļ¬cantly reduced the risk of breast cancer recurrence
55
Which of the following statement related to chemoprevention of cancer is wrong ?
Answer
C. The use of Ī±-tocopherol and Ī²-carotene leads to a decrease in the incidence of lung cancer
56
Approximately what percentage of all cancers is caused by smoking ?
Answer
B. 20%
57
Which of the following statements related to cervical cancer screening is wrong ?
Answer
B. Visual inspection with Lugolās lodine is more eļ¬ective in reducing mortality than using acetic acid.
58
Which of the following is false regarding oral cavity cancer screening and prevention in India ?
Answer
A. Oral visual examination screening in high-risk populations was recommended every 5 years for adults aged older than 50 years
59
Which of these factors reduces the risk of cancer of the colorectum ?
Answer
B. Dietary ļ¬bre
60
Which of the following increases the risk of prostate cancer ?
Answer
A. Insulin-like growth factor - 1
61
A 27-year-old female presents emergently to her Primary care physician with a 2-week history of epistaxis and gum bleeding. She has never had these symptoms before and she is not on any type of anticoagulant therapy. A CBC with PIt/Diļ¬erential shows a white blood count of 9500/mm3 (24% blasts), Hb 10.5 g/dL, and platelets of 92000/mm3 She is immediately referred to a Hematologist/Oncologist. A DIC panel reveals a 65 mg/dL ļ¬brinogen, PT >16 seconds, and PTT > 72 seconds. A bone marrow biopsy is performed and a formal diagnosis is pending. However, pathology comments that the premature white cells are HLA DR CD34 , MPO+, and CD33+. FFP and cryoprecipitate are being given to the patient. What should be done at this time ?
Answer
D. Start ATRA immediately.
62
Which of the following is not a favorable prognostic factor for AML patients ?
Answer
A. t(8;21)
63
Which of the following statements is not true about MRD in ALL ?
Answer
C. Semi-quantitative PCR is currently the only way to clinically assess MRD
64
L and H reed-Sternberg cells are the neoplastic cells of NLPHL. These cells arise from which of the following :
Answer
A. Germinal center B cells
65
Which of the following is not a factor in the Mantle Cell Lymphoma International Prognostic Index (MIPI) ?
Answer
D. Ann Arbor stage
66
Which of the following statements is false about advanced stage DLBCL?
Answer
C. Maintenance rituximab improves outcomes in patients with activated B cell advanced stage DLBCL
67
The most common chromosomal abnormality in CLL is
Answer
A. Del(13q)
68
Which of the following is not considered a classic end-organ damage criterion in the diagnosis of myeloma ?
Answer
B. Serum creatinine >2.5 mg/dL
69
Which of the following is not true about acute GVHD ?
Answer
B. The incidence of acute GVHD is higher with male donor.
70
The modiļ¬ed Seattle criteria used to deļ¬ne hepatic SOS include all of the following except
Answer
A. Serum conjugated bilirubin > 3 mg/dL
71
In a patient with locally advanced transitional cell cancer of the bladder with chronic pelvic and abdominal pain. Which of the following is MOST IMPORTANT in determining the maximum dose of oral morphine during dose titration?
Answer
A. Pain relief
72
Pharmacologic tolerance develops to all the following side eļ¬ects of opioid analgesics except
Answer
B. Constipation
73
A 25-year-old man was recently diagnosed with leukemia. He is admitted to the hospital for further evaluation and chemotherapy initiation. He only complains of fatigue and malaise. Laboratory evaluation reveals pancytopenia, hyperkalemia (K 6.8), uric acid 13, hyperphosphatemia (12), and elevated lactate dehydrogenase (LDH). What is the most likely cause of his electrolyte abnormalities ?
Answer
A. Tumor lysis syndrome
74
A 75-year-old man with lung cancer was admitted to the hospital with worsening dyspnea. He has complained of progressive dyspnea for 2 months. On physical examination, he has distended jugular veins, a plethoric face, venous collaterals on his chest wall, and distant heart sounds. What is the most likely diagnosis ?
Answer
D. Superior vena cava syndrome
75
A 74-year-old woman who has a history of breast cancer presents to the clinic with complaints of mild headache for the past few weeks. She describes daily retro-orbital headaches that get worse in the morning. In addition, she does vomits. MRI of the brain reveals multiple metastatic lesions. Which of the following is the most appropriate initial management for this patient ?
Answer
D. Dexamethasone
76
A 32-year-old woman who had an history of abortion 3 months back presented with lung metastases and brain involvement. Which of the following is the preferred treatment option in this patient ?
Answer
A. EMA/CO regimen (Etoposide, Methotrexate, Actinomycin D, Cyclophosphamide, Vincristine) where methotreaxate dlose is modiļ¬ed to 1000mg/m2.
77
A 60-year-old female with metastatic lung adenocarcinoma tests positive for a RET fusion mutation. Which targeted therapy should be initiated as ļ¬rst-line treatment ?
Answer
C. Selpercatinib
78
Which of the following statements regarding ADAURA trial for adjuvant therapy in non- small cell lung cancer is correct ?
Answer
D. There was an 83% reduction in the risk of disease recurrence or death, in the Osimertinib group compared to placebo group
79
A 5-year-old male presents with a recurrent medulloblastoma. Molecular testing reveals ampliļ¬cation of the MYC oncogene. What is the implication of this ļ¬nding in medulloblastoma ?
Answer
D. It is associated with a worse prognosis and resistance to treatment.
80
A 55-year-old postmenopausal woman presents with metastatic breast cancer to the bones. Immunohistochemistry of the primary tumor shows positive estrogen receptor (ER) and progesterone receptor (PR) expression, but negative HER2/neu expression. What is the most appropriate systemic therapy for this patient ?
Answer
D. Letrozole plus cdki
81
A 30-year-old prenienopausal woman diagnosed with breast cancer undergoes breast cancer surgery, chemotherapy and radiotherapy Her biopsy conļ¬rms the diagnosis of invasive ductal carcinoma (IDC), estrogen receptor-positive (ER+), progesterone receptor-negative (PR-), and HER2-negative. She is started on tamoxifen. with Luperolide. She is desirous of pregnancy. What advice would you give ?
Answer
C. To stop Tamoxifen after 2 years and then plan pregnancy safely
82
A 50-year-old woman presents for a routine mammogram. She has no signiļ¬cant medical history and no family history of breast cancer. The mammogram reveals an irregular mass with spiculated margins in upper outer quadrant of the right breast. There is also microcalciļ¬cation noted adjacent to the mass. No axillary Iymphadenopathy is visualized. The patient is asymptomatic and reports no breast changes. Based on the mammogram ļ¬ndings described, What is the most likely BI-RADS category for this lesion ?
Answer
B. BI-RADS 4
83
A 60-year-old male presents with metastatic melanoma. Molecular testing reveals BRAF V600 mutation-negative status. He has previously received chemotherapy with limited response. Upon further evaluation his tumor shows high expression of programmed death-ligand 1 (PD- L1). The patient is otherwise healthy with an Eastern Cooperative Oncology Group (ECOG) performance status of 1. The patient experiences immune-related adverse events (irAEs) during treatment. Which organ system is most commonly aļ¬ected by irAEs associated with immune checkpoint inhibitors ?
Answer
A. Gastrointestinal tract
84
A 45-year-old male presents with a painless mass in the left side of his neck for the past two months. He reports a history of oral sex with multiple partners and occasional tobacco and alcohol use. Biopsy of the tonsillar lesion conļ¬rms the presence of human papillomavirus (HPV) and squamous cell carcinoma.Which of the following statements regarding the prognosis of HPV-positive head and neck cancer is true?
Answer
D. HPV-positive tumors have a better prognosis and improved response to treatment compared to HPV-negative tumors.
85
A 52-year-old female presents to the clinic with complaints of abdominal bloating, pelvic discomfort, and increased urinary urgency for the past three months. She has no signiļ¬cant past medical history, but her maternal aunt was diagnosed with ovarian cancer at the age of 55. Imaging studies reveal a complex cystic mass measuring 8 cm in diameter arising from the ovary. CA-125 levels are signiļ¬cantly elevated. What is the most common histological subtype of ovarian cancer ?
Answer
A. Serous carcinoma
86
In addition to BRCA mutations, which other biomarker has been associated with potential response to PAR P inhibitors in ovarian cancer ?
Answer
C. ATM mutations
87
Which of the following populations should receive catch-up vaccination with the HPV vaccine after shared decision, according to CDC recommendations ?
Answer
B. Men who have sex with men (MSM) up to age 45
88
Which of the following is NOT an adverse eļ¬ect frequently associated with Cetuximab therapy in patients with colorectal cancer ?
Answer
B. Venous thrombosis
89
A 35-year-old otherwise healthy male presents with a progressively enlarging painless mass on his right thigh over the past six months. He denies any history of trauma to the area. Physical examination reveals a ļ¬rm, non-mobile mass measuring approximately 8 cm in diameter. There are no palpable regional lymph nodes. Magnetic resonance imaging (MRI) of the thigh demonstrates a well-deļ¬ned soft tissue mass with heterogeneous enhancement. Given the clinical presentation and imaging ļ¬ndings, which of the following is the most likely diagnosis ?
Answer
D. Synovialsarcoma
90
Which of the following targeted therapies is indicated for the treatment of metastatic colorectal cancer with BRAF V600E mutations, in combination with encorafenib and cetuximab?
Answer
C. Vemurafenib
91
Lenvatinib was granted accelerated approval by the FDA for the treatment of which of the following advanced cancers based on the results of the SELECT trial ?
Answer
B. Thyroid cancer
92
A 15-year-old male presents with fatigue, easy bruising, and recurrent infections over the past few weeks. Laboratory investigations reveal pancytopenia, with markedly elevated blast cells in the peripheral blood smear. Bone marrow biopsy conļ¬rms the diagnosis of acute myeloid leukemia (AML) with FLT3-ITD mutation. Which of the following targeted therapies is most likely to be eļ¬ective in the treatment of this patientās AML ?
Answer
C. Midostaurin
93
Which of the following statements regarding the use of lorlatinib in this patient population is most accurate ?
Answer
A. Lorlatinib is primarily indicated as salvage therapy after failure of prior ALK inhibitor treatment
94
Which of the following best describes the mechanism of trastuzumab-induced cardiotoxicity ?
Answer
C. Disruption of HER2 signaling pathway leading to cardiomyocyte apoptosis and dysfunction
95
A 9-year-old girl presents with a large, painful mass in her pelvis. Imaging studies reveal a 12 cm mass involving the pelvic bones with inļ¬ltration into adjacent soft tissues. Biopsy conļ¬rms the diagnosis of alveolar rhabdomyosarcoma. In addition to future tumor size and extent of invasion, which of the following molecular markers is most relevant for risk stratiļ¬cation in this patient ?
Answer
C. PAX3-FOXO1 fusion gene status
96
Which of the following statement regarding Burkitt lymphoma in children is true ?
Answer
C. Rituximab is an eļ¬ective drug in the treatment of Burkitt lymphoma
97
A 3-year-old child presents with abdominal distension and a palpable mass right ļ¬ank. Imaging studies reveal a 7 cm mass arising from the right adrenal gland with no evidence of distant metastasis. Biopsy conļ¬rms the diagnosis of neuroblastoma with favourable pathology and N-myc ampliļ¬cation positive. Which of the following is the most appropriate treatment approach for this patient ?
Answer
A. Chemotherapy followed by surgical resection and consolidation therapy with transplant
98
In a 7-year-old child with Wilms tumor, preoperative chemotherapy is administered to shrink the tumor before surgery. Upon histopathological examination of the nephrectomy specimen, there is evidence of minimal tumor necrosis, with viable tumor cells comprising approximately 70% of the specimen. What is the most appropriate next step in the management of this patient based on the pathological response ?
Answer
A. Administration of additional cycles of chemotherapy
99
Which of the following statement best describes borderline operable pancreatic cancer ?
Answer
A. Encasement of superior mesenteric artery less than 180 degree
100
Which statement accurately describes the patient population enrolled in the KEYNOTE- 177 trial in metastatic colorectal cancer ?
Answer
D. Patients with MSI-H or dMMR mCRC
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