| Post Name | ASSISTANT PROFESSOR IN NEPHROLOGY - MEDICAL EDUCATION SERVICES |
|---|---|
| Question Paper Code | 004/2021/OL |
| Category Code | 012/2020 |
| Date of Test | 8 March 2021 |
| Exam Type | Online Examination |
| Total Questions | 100 |
1
Which of the following statement about transplant immunosuppressive drugs is NOT TRUE ?
Answer
A. Cyclosporin binds to FK 506 binding protein in the cytoplasm and inhibits calcineurin
2
Which one of the following is an inhibitor of vascular calciļ¬cation in CKD ?
Answer
D. Fetuin-A
3
Erythrocytosis in patients with CKD is seen in all of the following conditions EXCEPT
Answer
B. Chronic allograft Nephropathy
4
Which of the following statement IS TRUE regarding FGF 23 a key regulator in bone and mineral metabolism in CKD ?
Answer
A. Its chief action is to reduce phosphate reabsorption in the proximal tubule
5
All of the following are side eļ¬ects of Carbonic anhydrase inhibitor (acetazolamide) use, EXCEPT
Answer
C. Symptomatic metabolic alkalosis
6
Which of the following drug combinations is considered unacceptable or ineļ¬ective in treating Hypertension ?
Answer
A. Beta-blockers and central adrenergic agents (eg. clonidine)
7
Identify the INCORRECT statement about the biomarkers in pre-eclampsia.
Answer
D. Urinary levels of PIGF are signiļ¬cantly higher in women who develop pre-eclampsia
8
Mutation in the gene coding for 11 Beta hydroxysteroid dehydrogenase Type 2 will result in
Answer
D. Syndrome of Apparent Mineralocorticoid Excess (SAME)
9
Inorganic phosphate is almost exclusively reabsorbed in
Answer
A. Proximal tubule
10
Which of the following statement about the characteristic of the dialyzer is NOT TRUE ?
Answer
C. High ļ¬ux dialyzers have low membrane permeability
11
The dialysis nurse wants to neutralize the excess dose of Heparin which he had accidentally given to the patient. What is the dose of Protamine required to neutralize 1000 IU of Heparin ?
Answer
B. 10 mg
12
Which of the following is a FALSE statement about Peritoneal dialysis solutions ?
Answer
A. Bicarbonate is the most commonly used buļ¬er in Peritoneal dialysis solutions
13
Identify the WRONG statement about calcium oxalate nephrolithiasis.
Answer
B. Bariatric surgery is used as a treatment for enteric hyperoxaluria
14
Renin-angiotensin aldosterone axis all statements about this are true EXCEPT
Answer
Question Cancelled
15
Macula densa is the specialized region in the
Answer
B. Loop of Henle
16
Which among the following autoantibody is NOT associated with membranous nephropathy ?
Answer
D. Soluble urokinase-type Plasminogen Activator Receptor (suPAR)
17
In tubuloglomerular feedback the correct statement about adenosine is
Answer
A. Vasoconstrictor mediator of the aļ¬erent arteriole
18
The bulk of Magnesium (Mg) is reabsorbed in which part of the tubule ?
Answer
B. Thick Ascending limb of Loop of Henle (TAL)
19
Which of the following is known as "Phosphatonin" ?
Answer
D. FGF23
20
Which among the following oral antidiabetic drug act by inhibiting renal tubular glucose absorption ?
Answer
B. Canagliļ¬ozin
21
The most likely primary cause of an acquired form of Nephrogenic Diabetes insipidus is
Answer
A. Down regulation of Aquaporin 2 receptor (AQP2)
22
Brain Natriuretic Peptide (BNP) is primarily synthesized in
Answer
B. Cardiac ventricles
23
Following are the renal complications of Non-steroidal anti-inļ¬ammatory drugs EXCEPT
Answer
D. Hypokalemia
24
Barters syndrome is characterized by all EXCEPT
Answer
B. Hypocalcuria
25
In aminoglycoside nephrotoxicity following electrolyte disturbance is found
Answer
D. All of the above
26
Which among the following variants of FSGS, is particularly frequent in secondary forms of FSGS mediated by adaptive structural-functional responses ?
Answer
B. FSGS, perihilar variant
27
Which among the following statement is/are false ? I. Familial IgA nephropathy may have a good prognosis. II. Macrohematuria is a more common presentation than asymptomatic microscopic haematuria, especially in the Asian population. III. It is more frequent in white people and Asians than in African Americans. IV. Mesangial IgA deposits are also present in 4-16% of normal, healthy adults, living and cadaveric donors.
Answer
A. I and II
28
Causes of linear staining on direct immunoļ¬uorescence of renal tissue includes I. Anti-GBM disease II. Older patients with hypertensive vascular disease III. Fibrillary nephritis. IV. Transplant biopsies.
Answer
D. I, II, III and IV
29
The primary goal of the 0 by 25 initiative of the International Society of Nephrology is
Answer
C. To prevent avoidable deaths related to AKI by 2025
30
Which of the following statements is false regarding Glomerulonephritis associated with Complement Disorders ?
Answer
C. C3 Nephritic Factor (C3NeF) is present in the majority of patients C3 glomerulonephritis and approximately 50% of patients with DDD
31
All are markers of AKI (Acute Kidney Injury) EXCEPT
Answer
D. Urinary MCP-1
32
According to KDIGO classiļ¬cation system albuminuria Stage A2 is characterized by
Answer
C. Urine albumin to creatinine ratio 30-300 mg per gram of creatinine
33
In classiļ¬cation of Diabetic kidney disease by histology, Stage 3 is characterized by
Answer
C. Nodular sclerosis (Kimmelsteil-Wilson Lesion)
34
Which of the following parasite localizes in the bladder wall ?
Answer
B. Schistosoma hematobium
35
Quantitative counts of bacteria in the suprapubic aspiration specimen of urine for microbiologic diagnosis of Urinary tract infection in patients not receiving antimicrobial therapy is 2
Answer
D. Any growth
36
Which of the following variable is NOT USED to estimate kidney function from Plasma Creatinine in four-variable MDRD (Modiļ¬cation of Diet in Renal Disease) equation ?
Answer
D. Weight
37
Which of the following statement is NOT TRUE about Vasopressin ?
Answer
A. Synthesized in the posterior pituitary
38
Mark the best response from the statement below on medication associated hyperkalemia.
Answer
D. All the above statements are true
39
The drug of choice for treatment of ethylene glycol induced acidosis is
Answer
C. Intravenous Fomepizole
40
Drug induced Distal RTA
Answer
A. Amphotericin B
41
Patiromer a cation exchange polymer is used in managing
Answer
B. Hyperkalemia
42
Which of the following gene defect is seen in Type 3 Bartter's syndrome ?
Answer
D. Chloride channel (CIC-Kb)
43
Streptococcal antigens implicated in the pathogenesis of post-streptococcal Glomerulonephritis
Answer
C. Both 1 and 2
44
Which one among the following Leptospira species are not pathogenic in human ?
Answer
D. Leptospira biļ¬exa
45
Quartan malarial nephropathy is caused by chronic or repeated infections by
Answer
C. P. Malariae
46
Intestinal pathogenic E.coli implicated in HUS (Hemolytic Uremic Syndrome)
Answer
A. Enterohemorrhagic E.coli (EHEC)
47
Identify the wrong statement about Dialysis associated Amyloidosis.
Answer
B. Eprodisate is the speciļ¬c treatment for this condition
48
Polymorphism of which gene is implicated in inļ¬uencing the therapeutic drug levels of Tacrolimus ?
Answer
D. CYP3A5
49
Approved systemic therapies for metastatic renal cancer are all EXCEPT
Answer
B. Tacrolimus
50
Gene mutations with causal links to FSGS (Focal Segmental Glomerulo Sclerosis)
Answer
D. All the above
51
Find the wrong statement about Hepatitis B Virus associated renal disease
Answer
A. Hepatitis B virus associated renal disease is more common in Hepatitis B carriers
52
Which of the following pharmacotherapy is used as a urease inhibitor in infection-related stones ?
Answer
C. Acetohydroxamic acid
53
All are conditions associated with Type B Lactic acidosis EXCEPT
Answer
D. CO poisoning
54
Classical hallmark of ATN on histological examination is
Answer
C. Loss of apical brush border of PCTs (Proximal Convoluted Tubules)
55
All of the following drugs can cause crystalluria EXCEPT
Answer
D. Cimetidine
56
Which cause of nephrotic syndrome have highest incidence of renal vein thrombosis, pulmonary embolism and deep vein thrombosis ?
Answer
C. Membranous Glomerulonephritis
57
The most common cause of medullary nephrocalcinosis is
Answer
C. Primary hyperparathyroidism
58
Autoantibodies strongly associated with scleroderma renal disease
Answer
D. Anti-RNA polymerase 3
59
Gitelman's syndrome distinguished from Bartter's syndrome by
Answer
D. Hypomagnesemia and hypocalcuria
60
Inherited renal tubular disorder characterized by persistent isolated glycosuria in the absence of hyperglycaemia is due to a mutation in
Answer
B. SLC5A2
61
Vascular manifestations of ADPKD include
Answer
D. All of the above
62
HCV induced immune complex disease is associated with
Answer
D. All of the above
63
Fabry's disease, all statements are true EXCEPT
Answer
C. In Fabry's disease angiokeratomas are most dense over the nape of the neck
64
Stains used to enhance basement membrane structure in renal biopsy
Answer
C. Jones methenamine silver
65
Following improve the biocompatibility of a dialysis membrane.
Answer
B. Less free hydroxyl groups on the membrane surface
66
Size of the urea molecule and creatinine molecule is
Answer
B. 60 Da and 113 Da, respectively
67
All of the following are used in managing recurrent intradilytic hypotension EXCEPT
Answer
B. Warm dialysate
68
Leucocyte esterase test, which indicates the presence of leucocytes in urine is present in all EXCEPT
Answer
B. Lymphocytes
69
Shape of urine crystals gives a clue to the chemical composition of urinary stones. Identify the wrong match from the following pair of crystal shape and chemical composition.
Answer
A. Coļ¬n lid appearance-Calcium oxalate monohydrate
70
GFR equations used to estimate GFR in paediatrics is
Answer
C. Schwartz equation
71
C3 nephritic factor is an autoantibody associated with
Answer
B. Type 2 MPGN
72
Electron microscopic ļ¬ndings characteristic of post-infectious Glomerulonephritis is
Answer
D. Irregular, hump like deposits on top of Glomerular basement membrane
73
Essential criteria for diagnosing Syndrome of inappropriate antidiuretic hormone secretion (SIADH)
Answer
D. All the above
74
Which of the following statement on the pharmacokinetics of loop diuretics is false ?
Answer
A. Toresamide have lesser oral availability than furosemide
75
Chinese herb nephropathy is due to
Answer
D. Aristolochic acid
76
Crescentic Glomerulonephritis is the histologic lesion in which of the following drug induced glomerulopathy ?
Answer
Question Cancelled
77
Gene defects associated with FSGS (Focal Segmental Glomerusclerosis).
Answer
D. All of the above
78
Which of the following feature is not a part of Lithium nephrotoxicity ?
Answer
C. Hypocalcemia
79
Which among the following is a selective antagonist of BAFF which is used as a novel therapy in IgA nephropathy ?
Answer
B. Blisibimod
80
Which of the following study showed ļ¬rst demonstrated that overt diabetic nephropathy can be prevented in type 2 DM with microalbuminuria ?
Answer
D. IRMA-2 trial
81
Kaplan-Meir method is used in a clinical trial for
Answer
C. Survival analysis
82
Number Needed to Treat (NNT) is computed based on
Answer
D. Absolute risk reduction
83
Randomised clinical trial is a typical clinical trial of
Answer
C. Phase 3
84
In the amendment to the THOTA (Transplantation of Human Organ and Tissue Act) 1994, the THOTA Rules 2014, the following changes were introduced EXCEPT
Answer
C. The number of doctors for certifying brain death is reduced to two doctors from the previous rule of 4 doctors
85
Which one of the following is a Neprilysyn inhibitor ?
Answer
D. Sacubitril
86
Which one of the following personality is generally regarded as the father of Nephrology ?
Answer
A. Richard Bright
87
Indications for parathyroidectomy in Chronic kidney disease is all EXCEPT
Answer
D. Adynamic bone disease on bone biopsy
88
Ferroportin is an
Answer
B. Cellular Iron Exporter
89
Which of the following complement component is involved in opsonisation ?
Answer
A. C3b
90
Risk factor and triggering factors in nephrogenic systemic ļ¬brosis caused by Gadolinium-based contrast agent in CKD are all EXCEPT
Answer
Question Cancelled
91
Combined liver-kidney transplantation is the best option for
Answer
D. Primary Oxalosis
92
Which one of the following drug can be considered as therapeutic option in post-transplant Thrombotic Microangiopathy (TMA) ?
Answer
A. Belatacept
93
Which of the following is NOT true regarding alloantigen presentation to T-cells ?
Answer
C. The MHC class I system is designed to present extracellular proteins taken up and processed by antigen presenting cells
94
Regarding post-transplant erythrocytosis, which of the following is false ?
Answer
D. It generally aļ¬ects those with poor allograft function
95
Regarding PTLD, which of the following is FALSE ?
Answer
C. Tacrolimus has a strong antiproliferative eļ¬ect on PTLD derived B cell lines
96
Which among the following statements is FALSE regarding lymphocele ?
Answer
D. Wound suction drains should not be removed postoperatively until less than 100 ml of ļ¬uid is produced on 2 consecutive days
97
Which among the following is NOT an absolute contraindication to renal transplantation ?
Answer
D. Positive B cell CDC (Compliment Dependant Cytotoxicity) crossmatch
98
The immunosupressive drug which blocks Interleukin 2 thereby preventing the proliferation of T-lymphocytes
Answer
D. Basiliximab
99
All of the following mediate Acute Kidney Injury (AKI) via impaired Microvascular Hemodynamics EXCEPT
Answer
D. Sulfonamides
100
As per the transplantation of human organs and Tissues Act-1994 (India), Unrelated transplant can be done only with the approval of
Answer
C. Authorisation Committee
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