| Post Name | Assistant Professor in Neurology - Medical Education |
|---|---|
| Question Paper Code | 024/2024/OL |
| Category Code | 336/2023 |
| Date of Test | 16 March 2024 |
| Exam Type | Online Examination |
| Total Questions | 100 |
1
In muscle spindle, the term annulospiral endings is given for
Answer
A. Group la ļ¬bers
2
Which nucleus of amygdala has connections with hypothalamus?
Answer
B. Centromedial
3
Neural groove is formed on Day
Answer
B. 18
4
34 year old male presents with progressive distal Right upper limb weakness in the distribution of median and ulnar nerves with no sensory symptoms. What is the likely diagnosis?
Answer
C. Multifocal motor neuropathy
5
A 45 year old male presents with weakness in left arm abduction and sensory loss over the lateral surface of the left upper arm and shoulder. Damage to which of the following structures of the brachial plexus may cause this presentation?
Answer
C. Posterior cord
6
A 62-year-old man is seen for subacute onset of generalized weakness and gait changes with diļ¬use decreased reļ¬exes and CIDP is suspected. Which of the following clinical and laboratory ļ¬ndings is concerning for the diagnosis of POEMS syndrome as opposed to CIDP?
Answer
D. Presence of lambda light chain
7
A 44-year old man presents for evaluation of weakness. He reports the onset of diļ¬culty in swallowing and weakness in his arms 3 year prior, which was initially attributed to statin therapy but has continued to progress oļ¬ the statin. He reports progression of weakness and is detected to be diabetic. He has tongue and peri oral fasciculations, bilateral deltoid and iliopsoas weakness with atrophy and fasciculations. Absent ankle jerk; trace reļ¬exes and ļ¬exor plantar and intact sensation. Which of the following additional features would be expected on examination?
Answer
C. Gynecomastia
8
A 13-year old boy presents with muscle pain and stiļ¬ness which is much worse in cold weather. In fact, few hours after exposure to cold, he felt quite weak as well as stiļ¬. He had percussion myotonia at the thenar eminence and eye closure myotoria. Mutation in which of the following channels is mots likely responsible for his presentation?
Answer
D. Sodium
9
20-year-old male presents for evaluation of abnormal movements. He initially developed dystonia of his left leg at 10 year of age, associated with walking and running. No response to levodopa, and trihexyphenidyl. He was successfully treated with Botulinum injections. However, he progressed to have dystonia in his right arm. His 57 year old father has Write's cramp and his younger sister has recently developed suspected dystonia in her legs. Mutation in which of the following genes is the most likely cause of the dystonia?
Answer
D. Torsin A
10
Which of the following is not a structure involved in the formation of new memories within the circuit of paper?
Answer
C. Mediodorsal nucleus of the thalamus
11
Associative visual agnosia is caused by a lesion in the
Answer
C. Inferotemporal cortex
12
All the following statements are correct regarding Foville syndrome except:
Answer
D. Presence of Ipsilateral VI, VII, IX, X and contralateral ataxia
13
Which of the following correlates with decorlicate rigidity?
Answer
D. Disinlibition of the red nucleus with facilitation of the rubrospinal tracts
14
A 30-year-old lady is evaluated for recurrent episodes of severe, repetitive stabbing pain in the right forehead and temple that is associated with ipsilateral conjunctival injection, tearing and photophobia. The attacks last between 1 and 2 minutes and occur atleast 100 times daily. Which of the following preventive measure is most likely to be eļ¬ective in this patient?
Answer
C. Lamotrigine
15
A 16 year old girl has 6 months history of early night-time episodes characterized by sudden arousal from sleep, lifting her head and dystonic posturing of the extremities sometimes followed by getting out of bed and ambulating around the room for 1 to 2 minutes. There is a history of similar symptoms in her brother, father and paternal grandmother. Mutation of which of the following genes is most likely to be present in this patient?
Answer
D. Neuronal nicotinic acetylcholine receptor
16
A 64-year-old man presents with a 1 year history of progressive memory loss and more recent onset of abnormal movements of his arms, legs and trunk. Then he has obstructive sleep apnoea. His wife, who accompanies him describes odd movements during sleep in which he appears to be performing his previous work activities, such as threading wires. On examination, he has a vertical gaze palsy. What is the most likely diagnosis?
Answer
B. Anti-EgLON 5 disease
17
A girl presenting with DMD phenotype is most likely to be
Answer
B. Sarcoglycanopathy
18
Which is a CSF synaptic biomarker for Alzheimer's disease?
Answer
C. Neurogranin
19
In which stage of intracerebral haemorrhage, both T1 and T2 MRI sequences are hyperintense?
Answer
D. Late subacute
20
Which of the following is one among the earliest electrophysiological ļ¬nding in Guillain Barre syndrome?
Answer
A. F wave impersistence
21
Ear of lynx sign is seen in
Answer
C. HSP type 11
22
False regarding QSART
Answer
A. Tests preganglionic sympathetic ļ¬bres
23
Changing the ļ¬lter settings on the EEG allows for all of the following except:
Answer
D. Preferential ampliļ¬cation of epiletiform discharges
24
The intracellualr pathophysiological mechanism of an epiletiporm discharge is
Answer
D. Paroxysmal depolarising shift
25
Insular Lobe seizures are characterized by all except
Answer
D. Complex gestural automatisms
26
In Transient Global Aphasia (TGA), the following are correct except
Answer
A. Impairment in state of consciousness
27
The anatomic structures of central importance in memory functions are the following except?
Answer
D. Red nucleus
28
The following is an example of implicit memory except?
Answer
C. Learning new material
29
The following are related to features of depression except?
Answer
Question Cancelled
30
The following are examples of subcortical dementias except?
Answer
D. Alzheimer's disease
31
Following Hemtopoietic Stem Cell Transplantation (HSCT) the following neurological complication can occur except?
Answer
Question Cancelled
32
The following drugs will produce cerebellar syndrome
Answer
Question Cancelled
33
Botulinum toxin A bind to following synaptic vesicular protein
Answer
Question Cancelled
34
Clinical improvement after the use of Edrophonium are seen in the following conditions except?
Answer
Question Cancelled
35
Therapeutic options for ADEM are except
Answer
D. Bone marrow transplantation
36
Reye Syndrome is characterized by following except
Answer
D. Oligo clonal bands
37
Monoclonal antibodies are used in Multiple Sclerosis are the following except
Answer
D. Eculizumab
38
Evoked Potentials used in early stages of Multiple Sclerosis or spinal form of multiple sclerosis are following except
Answer
A. Readiness potential
39
Multiple Sclerosis in conjunction with peripheral neuropathy indicative of following except
Answer
Question Cancelled
40
Recurrent myelitis at one level of spinal cord without any other signs of demyelinating disease can be found in except?
Answer
A. Multiple sclerosis
41
JC Virus causing Progressive Multifocal Leukoencephalopathy by attacking which cells of brain?
Answer
B. Glial cells
42
In SSPE histopathological changes are not observed in following part of brain?
Answer
D. Cerebellum
43
Infections that follow neurosurgery or the insertion of cranial appliances are usually due to
Answer
B. Staphylococcus
44
Eosinophilic meningitis is caused by following except
Answer
A. Cholesterol emboli
45
Drugs used for treating CNS toxoplasmosis are except
Answer
D. Levamisole
46
CNS Aspergillosis can occur as a complication of the following except?
Answer
D. Meningitis
47
Risk of stroke is implicated with polymorphism of which chromosome?
Answer
B. 12
48
CHADS2 and CHA2DS2-VASC are scoring system to predict the risk of stroke following
Answer
A. Atrial Fibrillation
49
Hollenhorst plaque is get in which organ?
Answer
B. Retina
50
Blood supply of Globus Pallidum is by
Answer
Question Cancelled
51
Transmantle sign is seen in the Magnetic Resonance imaging of which of the following conditions causing epilepsy?
Answer
C. Focal Cortical Dysplasia Type IIb
52
Which among the following statements is/are true regarding responsive Neurostimulation (RNS) treatment in epilepsy? I. It is synonymous with adaptive Deep Brain Stimulation II. Epilepsy arising from loci in the eloquent cortex is the major contra-indication for RNS III. It is a form of closed-loop neurostimulation IV. Useful in those with poorly localised or multi-focal epilepsy in whom resective surgery is contra-indicated
Answer
A. Only statement III is correct
53
Synaptic Vesicle Protein 2A (SV2A) mediates the anticonvulsant eļ¬ects of which of the following anti-seizure medications? I. Lacosamide II. Levetiracetam III. Ruļ¬namide IV. Stiripentol
Answer
D. Only II
54
Which among the following statements is true regarding Gastaut Syndrome?
Answer
B. Typical age of seizure onset is at 7-10 years of age
55
Epileptogenic Zone is most accurately deļ¬ned as
Answer
C. Zone whose resection is necessary and suļ¬cient to eliminate seizures
56
Mutations in which among the following genes is related to Autosomal Dominant Epilepsy with Auditory Features (ADEAF)?
Answer
D. Leucine-Rich Glioma Inactivated-1 (LG/1) gene
57
Select the correct statement/statements regarding the physiology of sleep and wakefulness. I. Cholinergic neurons located close to mesopontine junction are involved in maintenance of wakefulness. II. The major neurotransmitter for sleep-wake cycle, hypocretin, comes from neurons in the tuberomammillary nucleus. III. Neurons in the median preoptic nucleus are involved in the initiation of sleep. IV. Neurons in the lateral hypothalamus form the major source of histamine in the physiology of sleep
Answer
B. I and III are correct
58
Which among the following is classiļ¬ed as a parasomnia in the international classiļ¬cation of Sleep Disorders?
Answer
A. REM Sleep Behaviour Disorder
59
The "3P Model" or the Spielman model is the most widely accepted theoretical model of
Answer
A. Insomnia
60
The neurotoxin beta-N-oxalylamino-L-alanine (L-BOAA), responsible for lathyrism, is a:
Answer
C. AMPA Glutamate Receptor agonist
61
Skewed Lyonization impacts the clinical manifestations of which among the following diseases?
Answer
B. Kennedy disease
62
Which among the following statements regarding Upper Motor Neuron (UMN) Disorders is correct? I. Spastic Paraplegia 2 due to PLP1 mutations is inherited as an autosomal recessive condition. II. Konzo is a myelopathy predominantly seen in Tanzania and results from Human T Lymphotropic Virus Type 2 infection. III. Primary Lateral Sclerosis is a diagnosis of exclusion. IV. Magnetic Resonance Spectroscopy shows reduction in choline relative to N-acetyl aspartate in patients with UMN syndrome in motor neuron disease.
Answer
D. Only III is correct
63
Tofersen is a novel drug being tried in the treatment of Amyotrophic Lateral Sclerosis resulting from mutation in which among the following genes?
Answer
D. SOD1
64
Which among the following medications modulates the splicing of the Survival Motor Neuron 2 (SMN2) pre-mRNA?
Answer
C. Nusinersen
65
A 65-year-old lady comes to you with frequent headaches which are exclusively nocturnal. The headaches wake her up from sleep almost every night around midnight. The headache may last from 20-30 minutes, sometimes up to 2 hours. No medical comorbidities were reported. No abnormalities were found on clinical examination and baseline laboratory tests and MR imaging of brain were reported normal. Which among the following medications is likely to help this patient?
Answer
B. Caļ¬eine
66
Which among the following neurons in the cerebellum are glutaminergic and excitatory?
Answer
A. Granule cells
67
All the following Spinocerebellar Ataxias (SCAs) are caused by polyglutamine-coding CAG repeat expansions, EXCEPT
Answer
C. SCA10
68
Select the correct statement/statements regarding autosomal recessive ataxias. I. In Ataxia Telangiectasia Like Disorder, serum Alphafeto Protein (AFP) levels are typically normal. II. Serum AFP levels are elevated in Ataxia with Oculomotor Apraxia Type 2. III. Lymphoid cancer risk in Ataxia with Oculomotor Apraxia Type 2 is even higher than Ataxia Telangiectasia. IV. Ataxia with Oculomotor Apraxia Type 1 is associated with immunodeļ¬ciency.
Answer
D. I and II are correct
69
The delayed-start study design is used to:
Answer
B. Separate disease-modifying eļ¬ects of study-drug, from its eļ¬ects on symptoms
70
Which among the following "apraxias" is most likely to occur as a treatment-related complication in patients with Parkinson's diease undergoing bilateral subthalamic nucleus deep brain stimulation?
Answer
B. Apraxia of eye lid opening
71
Which among the following is a 3 Repeat (3-R) tauopathy?
Answer
C. Pick's disease
72
The landmark clinical trial, PD-MED, whose results were published in 2014, compared which of the following therapies in Parkinson's disease?
Answer
A. Levodopa, Dopamine agonists and Monoamine Oxidase-B inhibitors
73
What is the approximate penetrance in DYT-TOR1A (TOR-1A Associated dystonia)
Answer
D. Around 30%
74
Which among the following is the most characteristic histological features linking the diļ¬erent types of Multiple System Atrophy?
Answer
D. Glial cytoplasmic inclusions
75
Ambroxol, which has been tried as a candidate drug for repurposing for the treatment of Parkinson's disease, acts on which of the following mechanisms?
Answer
B. Glucocerebrosidase pathway
76
Identify the correct statement
Answer
D. All are correct
77
Identify the incorrect combination.
Answer
D. Rapid acetylators - high risk for INH polyneuropathy
78
Predominant upper limb motor involvement is the typical pattern in all except
Answer
D. Familial Amyloid neuropathy
79
A 32-year, premorbidly normal lady, developed gait unsteadiness followed by double vision and drooping of eyelids. She had mild sore throat a week ago and clinical examination revealed bilateral external ophthalmoplegia, subtle bifacial weakness and ataxia. The most likely diagnosis.
Answer
B. Miller Fisher syndrome
80
In Hereditary Neuropathy with Liability to Pressure Palsies (HNPP), the most frequently aļ¬ected never is
Answer
A. Fibular nerve
81
Features of Musk-Antibody Myasthenia Gravis include all except
Answer
D. Have prominent thymic changes
82
"Ice pack test" in Myasthenia Gravis
Answer
A. Has high sensitivity and speciļ¬city
83
Thymectomy for Myasthenia Gravis (MG)
Answer
D. Thymectomy should be considered in all early-onset AChR MG patients
84
Which of the following statement is wrong about Lambert-Eaton Myasthenia (LEM)?
Answer
C. Anti VGCC Antibodies are usually negative Non-Cancer Associated LEM
85
Incorrect statement about Congenital Myasthenic Syndrome
Answer
D. Episodic respiratory crises occur only in choline acetylcholinesterase (ChAT) deļ¬ciency
86
In the treatment of Duchenne Muscular Dystrophy (DMD) which of the following is incorrect?
Answer
C. Eteplirsen oļ¬er curative therapy
87
Sudden death secondary to fatal arrhythmias is common in
Answer
B. LGMD 1B
88
Asymmetric weakness, deltoid sparing and Positive Beevor sign seen in
Answer
A. FSHD
89
Incorrect about Immune mediated Myopathy associated with Anti- HMGCoA Reductase antibodies
Answer
D. Immunotherapy is ineļ¬ective
90
Muscle inļ¬ltration with aberrant large granular T lymphocytes may be seen in which of the following?
Answer
A. Inclusion Body Myositis
91
Which of the following is not known to produce 'secondary pseudotumor cerebri'? Superior vena cava syndrome
Answer
C. Topiramate
92
Low cerebellar tonsils, crowding of the posterior fossa, small prepontine cistern and inferior displacement of the optic chiasm are seen in
Answer
C. Spontaneous spinal CSF leaks
93
Which of the following is not an anti-migraine agent?
Answer
C. Felodipine
94
Identify the incorrect statement about SUNCT and SUNA.
Answer
A. Indomethacin eļ¬ective in 50% of patients
95
Pain felt deep in the auditory canal is suggestive of
Answer
B. Geniculate neuralgia
96
Treatment for self-multilation in Autistic Spectrum Disorders include all of the following except
Answer
Question Cancelled
97
Which of the following is not an atypical features in Dyslexia?
Answer
A. Male gender
98
Which of the following could be permitted for use in patients with Porphyria?
Answer
B. Chlorpromazine
99
A 16-year-old was operated for vestibular schwannoma on both sides within a span of 2 years. What is ophthalmological ļ¬nding most commonly encountered?
Answer
C. Posterior subcapsular cataracts
100
Which of the following is atypical for Panayiotopoulos Syndrome?
Answer
B. Prominent visual phenomena
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