| Post Name | Assistant Professor in Pharmacology - Medical Education |
|---|---|
| Question Paper Code | 028/2024/OL |
| Category Code | 349/2023 |
| Date of Test | 20 March 2024 |
| Exam Type | Online Examination |
| Total Questions | 100 |
1
Which of the following is an example for supra additive synergism?
Answer
B. Levodopa + Carbidopa
2
All are examples of pharmacogenetically mediated adverse eļ¬ects except
Answer
A. Tardive dyskinesia by neuroleptics
3
All the following molecules act through JAK/STAT receptors except
Answer
D. Thyroxine
4
Which of the following drugs produce phototoxicity? i. Amiodarone ii. Sulfonamides iii. Phenothiazines iv. Phenytoin
Answer
A. (i, ii, iii) only
5
Characteristic features of intramuscular route of drug administration i. Hypertonic solution can be injected ii. Only water solutions can be injected iii. Oily solutions can be injected
Answer
C. only iii
6
Which of the following statements are correct about Meta-analysis? i. Cannot prove cause and eļ¬ect ii. Evaluation and grouping of similar studies iii. Aim is to decrease the number of subjects studied
Answer
A. Only (i and ii)
7
Which statement is not true about transdermal therapeutic system?
Answer
C. more inter individual variations
8
Among the following combinations which is not a CYP3A4 substrate and its inhibitor?
Answer
D. Metoprolol - Nevirapine
9
All are indications of therapeutic drug monitoring except
Answer
B. Drugs with irreversible actions
10
Which of the following statements are correct about clinical trial? i. Phase I - Dose range, safety and etolerability, only in patients ii. Phase II - Therapeutic eļ¬cacy and dose range in patients iii. Phase III - Drug safety and tolerability in large number of patients iv. Phase IV - Therapeutic eļ¬cacy in large number of patients
Answer
B. (ii and iii) only
11
Systemic clearance of a drug is directly related with all the following except
Answer
C. Plasma half-life
12
Which statement is not true about OATP1B1 transporter?
Answer
C. Polymorphism increases transport of OATP1B1 substrates
13
Which schedule under the drugs and cosmetics rules, 1945 deals with the prescription of tramadol and pentazocine?
Answer
D. Schedule H1
14
Among the following benzodiazipines which is preferred in elderly individuals?
Answer
B. Lorazepam
15
Quality Adjusted Life Years (QALYS) is a measure of which pharmaco economic analysis
Answer
C. Cost-utility analysis
16
Botulinum toxin is beneļ¬cial in all except
Answer
B. post operative paralytic ileus
17
Among the following drugs which is not useful in acute congestive glaucoma
Answer
A. Dipivefrine
18
All are advantages of third generation Ī² blocker Nebivolol except
Answer
D. Slow onset of hypotensive response
19
All are properties of halothane except
Answer
B. Good analgesic agent
20
Which adverse eļ¬ect is more seen with pentazocin than with morphine?
Answer
C. Hypertension
21
All are AMPA blockers used as antiepileptic drugs except
Answer
D. Felbamate
22
Which of the following statement is not true about Agomelatine an atypical antidepressant drug?
Answer
C. Antagonist on 5HT2A receptor
23
All are adverse eļ¬ects of clozapine which is an atypical antipsycholic agent except
Answer
B. Acute muscular dystonia
24
Baclofen is a centrally acting skeletal muscle relaxant used to treat following clinical conditions except
Answer
Question Cancelled
25
All are properties of local anesthetic agent Ropivacaine i. Short acting ii. Less cardiotoxicity iii. Blocks A8 and C ļ¬bres completely iv. Used epidurally for labour pain
Answer
C. (ii, iii and iv) only
26
Which among the following beta blocker has the longest half life?
Answer
B. Bisoprolol
27
Which of the following calcium channel blockers can delay the progression of early stages of type I diabetes by improving the survival of pancreatic beta cells?
Answer
A. Verapamil
28
Choose the drug which attenuates platelet aggregation by antagonising thromboxane receptor :
Answer
A. Losartan
29
In patients with diabetes and chronic kidney disease which of the following drugs can reduce heart failure events and renal function decline
Answer
C. Finerenone
30
The following antiarrhythmic drug produces anticholinergic side eļ¬ects
Answer
C. Disopyramide
31
Which of the following drug is the ļ¬rst line therapy for severe Pulmonary Artery Hypertension (Functional Class IV)
Answer
D. Epoprostenol
32
Idarucizumab is a reversal agent for toxicity due to
Answer
A. Dabigatran
33
Which of the following antiplatelet drug has rapid onset of action and a circulating half life of 3 to 4 days?
Answer
D. Vorapaxar
34
Evolocumab is a
Answer
C. Proprotein convertase subtilisin/Kexin type 9 inhibitor
35
Thrombopoietin Receptor Agonist (TRAs) preferred in chronic hepatitis C virus (HCV) associated thrombocytopenia
Answer
B. Eltrombopag
36
GnRH agonist which can be given intranasally is
Answer
B. Nafarelin
37
Which of the following statement regarding methimazole is correct
Answer
A. is the drug of choice for Graves disease
38
Hypoactive Sexual Desire Disorder (HSDD) is treated with :
Answer
C. Ospemifene
39
Phosphodiesterase 5 (PDE5) inhibitor with maximum duration of action is
Answer
C. Tadalaļ¬l
40
Anti inļ¬ammatory potency is maximum for
Answer
D. Betamethasone
41
Inoperable adrenocortical carcinoma is treated with
Answer
A. Mitotane
42
Which of the following insulin preparation forms multihexameric complexes after sub cutaneous injection?
Answer
C. Degludec
43
The GLP-1 agonist approved for weight loss independent of diabetes status are i. Dulaglutide ii. Liraglutide iii. Lixisenatide iv. Semaglutide
Answer
C. only (ii and iv)
44
The following bisphosphonate is preferred in treatment of hypercalcemia because of its more rapid normalization of serum and longer duration of action
Answer
D. Zoledronate
45
The Vitamin D analogue used in the treatment of Psoriasis is
Answer
A. Calcipotriol
46
Diagnostic testing of cancer specimen for BRAF V 600 mutation is important in guiding treatment decision for the following drug
Answer
B. Trametinib
47
Most neurotoxic alkylating agent is
Answer
A. Ifosfamide
48
Which of the following drug is a very potent radiosensitizer and should not be used with radiotherapy?
Answer
C. Gemcitabine
49
Pancreatic Neuro Endocrine Tumor is treated with
Answer
D. Sunitinib
50
Abiraterone is used for the treatment of
Answer
B. Metastatic prostate cancer
51
Bedaquiline acts by
Answer
D. Inhibiting Adenosine 5'triphosphate synthase in mycobacteria
52
Guanosine analogue with antiretroviral action is
Answer
C. Abacavir
53
Orally eļ¬ective antifungal antibiotic capable of inducing microsomal enzymes is
Answer
A. Griseofulvin
54
An orange dye which exerts analgesic action in urinary tract is
Answer
C. Phenazopyridine
55
Advantages of Artemisinin based combination therapy include all except
Answer
C. High recrudescence rate
56
All are true about Linezolid EXCEPT
Answer
A. It is bactericidal against enterococci
57
Minocycline, in comparison to Doxycycline,
Answer
A. Attains higher concentration in tears and saliva
58
The antimicrobial agent eļ¬ective against pseudomonas is
Answer
B. Ticarcillin
59
Topically eļ¬ective sulphonamide preparation for bacterial conjunctivities is
Answer
C. Sodium Sulfacetamide
60
Orally eļ¬ective carbapenem, resistant to inactivation by renal dehydropeptidase is
Answer
D. Faropenem
61
The mismatched pair among the following is
Answer
Question Cancelled
62
All are uses of N Acetyl Cysteine except
Answer
A. Captopril induced dry cough
63
The CCK1/CCKA receptor antagonist that increases motility of the gastrointestinal tract is
Answer
D. Loxiglumide
64
New formula for WHO-ORS provides
Answer
B. 75 mM , 20mM , 65 mM
65
Emesis is induced by
Answer
D. Ipecacuanha
66
Active form of the Enkephalinase inhibitor, Racecadotril is
Answer
B. Thiorphan
67
In Rheumatoid arthritis, Anakinra acts by
Answer
A. Interleukin 1 receptor antagonism
68
Alprostadil eļ¬ective in Erectile dysfunction in males is a
Answer
D. analogue
69
Longest acting agonist is
Answer
B. Frovatriptan
70
The true statement about probenecid is
Answer
B. It should be taken with plenty of ļ¬uids
71
Orally eļ¬ective drug in scabies is
Answer
C. Ivermectin
72
Drug eļ¬ective in treatment of Vitiligo is
Answer
A. Trioxsalen
73
Nephrotoxicity is less common with the use of
Answer
D. Sirolimus
74
Immunostimulant action is exhibited by
Answer
A. Levamisole
75
Lowering of intraocular pressure is seen with the use of
Answer
C. Taļ¬uprost
76
Dimercaprol is contraindicated in
Answer
B. Cadmium poisoning
77
Povidone lodine is an example for
Answer
D. Iodophore
78
Find the wrong pair
Answer
B. Gemtuzumab -CD3
79
Read the assertion and reason statements and choose the single best response Assertion (A) : Sildenaļ¬l causes impaired blue green discrimination Reason (R): Sildenaļ¬l is a weak inhibitor of phosphodiesterase 6
Answer
A. Both (A) and (R) are true and (R) is the correct explanation of (A)
80
False statement about lorcaserin is
Answer
C. It is a cannabinoid receptor antagonist
81
Experimental animal commonly used for pyrogen testing
Answer
C. Rabbit
82
According to prevention of Cruelty to Animals Act 1960, deļ¬nition of 'animal' includes all except
Answer
B. Human beings
83
Sodium dihydrogen phosphate is a constituent of
Answer
D. Tyrode solution
84
Which of the anesthetic agents is not suitable for the study of cardiovascular drugs in experimental animals
Answer
C. Pentobarbitone
85
Which among the following can be used as a mobile phase in normal phase HPLC?
Answer
Question Cancelled
86
Which among the following is not used as a label in Radioimmunoassay
Answer
C. Iodine-127
87
Mean total cholesterol values of 50 diabetic patients is 346 mg/dl with standard deviation of 20 and that of non-diabetics is 288 mg/dl with standard deviation 9. To compare these values, which statistical test is the most appropriate?
Answer
A. Independent sample t test
88
According to the empirical rule, approximately what percentage of the date should lie within +/-2SD
Answer
C. 95%
89
If the data are normally distributed with a mean of 180 and standard deviation of 40. Between what two values will approximately 68% of the data fall
Answer
A. 140 and 220
90
In a box and whisker plot, two sides of the box represent
Answer
D. and percentiles
91
Bradykinin receptor antagonist useful for symptomatic treatment of hereditary angioedema
Answer
D. Icatibant
92
An endocrine disrupting chemical is
Answer
Question Cancelled
93
The preferred drug in type 2 diabetes mellitus patient with patient with cardiac failure
Answer
A. Empagliļ¬ozin
94
Which among the following is not an example of drug repurposing?
Answer
D. Topiramate for treatment of epilepsy
95
Which among the statements regarding Semaglutide is incorrect?
Answer
B. it causes weight gain in patients
96
The drug useful for controlling delusions, hallucinations and psychosis in parkinson's disease
Answer
B. Pimavanserin
97
Which among the following is not included in world Health Organisation's prescribing indicators
Answer
A. Percentage of encounters with tablets prescribed
98
Which among the following is a Watch drug as per Aware classiļ¬cation of antimicrobials?
Answer
Question Cancelled
99
The partial nicotine receptor agonist useful in smoking cessation
Answer
C. Varenicline
100
The assumed average maintenance dose per day for a drug used for its main indication in adults is
Answer
A. Deļ¬ned daily dose
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