| Post Name | Associate Professor/Reader in Physiology and Biochemistry |
|---|---|
| Question Paper Code | 070/2024/OL |
| Category Code | 178/2023 |
| Date of Test | 20 June 2024 |
| Exam Type | Online Examination |
| Total Questions | 100 |
1
N acetyl muramic acid is a derivative of
Answer
D. Rhamnose
2
Which of the following enzyme is inhibited by ļ¬ouride ions ?
Answer
B. Enolase
3
Pyruvate is converted to Acetyl CoA by
Answer
A. Pyruvate dehydrogenase
4
Amino acid that is entering into the TCA cycle as fumarate is
Answer
C. Phenylalanine
5
All are activators of gluconeogenesis except
Answer
B. Fructose 2,6 bisphosphate
6
Which of the following doesn't have any eļ¬ect on muscle glycogen phosphorylase ?
Answer
D. Glucagon
7
Action of insulin is all except
Answer
C. Ketone body synthesis
8
Which is not a feature of diabetic Keto acidosis ?
Answer
A. Hypernatremia
9
Factors that increase insulin secretion are all except
Answer
A. Epinephrine
10
Von Gierke's disease is characterised by all except
Answer
B. Hypouricemia
11
Alcohol not seen in phospholipids is
Answer
A. Mannitol
12
Which of the following is an example of polyunsaturated fatty acid ?
Answer
D. Linoleic acid
13
Which of the following is not a product formed during beta oxidation of fatty acids ?
Answer
C. Malonyl CoA
14
Lecithin cholestrol acyl transferase is activated by
Answer
B. Apo A1
15
Lipotropic factors include all except
Answer
D. Ethanol
16
Ammonia is formed by the action of all the following enzymes except
Answer
D. Alanine transaminase
17
H. H. H syndrome is characterised by all except
Answer
C. Hyper citrullinemia
18
Activity of glutamate dehydrogenase in liner is allosterically activated by
Answer
A. ADP
19
Which among the following is an exopeptidase ?
Answer
D. Carboxy peptidase
20
Phenylalanine hydroxylase deļ¬ciency causes which type of phenylketonuria ?
Answer
A. Type I
21
Conversion of heme to bilirubin release one molecule of
Answer
B. CO
22
All the following biochemical parameters are indices of synthetic function of liver except
Answer
D. S.Bilirubin
23
Choose the wrong statement regarding Graves' disease
Answer
B. TPO antibody high
24
In urine abnormal constituents study the result is as follows : Hays test positive, Modiļ¬ed Fouchet's test is positive, Ehrlich's test negative. What is the type of Jaundice ?
Answer
D. Post hepatic jaundice
25
The daily requirement of Vitamin D in children is
Answer
B. 600IU/day
26
Which of the following is a useful biomarker for Paget's disease
Answer
A. Alkaline Phosphatase
27
Choose the vitamin which has antioxidant property ?
Answer
C. Vitamin E
28
All the following are tests which assess tubular function of kidney except
Answer
A. Inulin clearance test
29
The cardiac biomarker that can be used to diagnose heart failure
Answer
B. Brain natriuretic peptide
30
The mineral necessary for collagen synthesis is
Answer
B. Copper
31
Anemia is a feature in all the following conditions except
Answer
A. Vitamin B1 deļ¬ciency
32
Which vitamin deļ¬ciency can occur in a patient on prolonged antibiotic therapy ?
Answer
B. Vitamin K
33
Which of the following statement is not true regarding Km value ?
Answer
C. Km value is decreased in allosteric inhibition of enzymes
34
All the following are selenium containing enzymes except
Answer
B. Xanthine oxidase
35
Which form of vitamin A has role in vision ?
Answer
C. Retinal
36
Indirect positive Vanden Bergh reaction is seen in all the following conditions except
Answer
C. Dubin Johnson syndrome
37
The marker of occult alcohol intake is
Answer
D. Gamma glutamyl transferase
38
Which of the following normal constituent of urine is excreted in decreased amount in liver disease ?
Answer
C. Urea
39
Polyuria is seen in all the following conditions except
Answer
B. SIADH
40
Creatinine clearance results are corrected using a patient's body surface area to account for diļ¬erences in
Answer
B. Body mass
41
In a person, the extracellular potassium concentration in body ļ¬uids is 7meq/L, intracellular potassium concentration is 4-5eq/L. Which of the following is true ?
Answer
B. Action potential would ļ¬re more easily
42
Which is not true about Goldmann-Hodgkin-Katz Equation ?
Answer
B. It deals with Ficks Law of diļ¬usion
43
The following is not true for G Protein receptors
Answer
C. The activity of Gprotein coupled receptors on target cell is due to Ī²Ć½ subunit
44
Sodium Potassium pump activity is increased by
Answer
B. Insulin
45
The following are features of Mobitz Type 1 block except
Answer
A. Constant PR interval
46
Which of the following biomarkers is released from ventricular myocytes ?
Answer
A. Brain natriuretic peptide
47
Splitting of second heart sound occurs
Answer
B. Closure of aortic valve occurs earlier than pulmonary valve
48
When a person changes position from standing to lying down posture, the following actions occur
Answer
B. Venous return to heart rises immediately
49
True regarding endothelin-1 are all except
Answer
A. Bronchodilation
50
True regarding vascularity of lung is
Answer
D. Distended pulmonary veins in lower lobe
51
Substance present in both serum and plasma is
Answer
B. Factor VII
52
The following is true for NK cell
Answer
D. Can kill virus infected and cancer cells
53
Eļ¬ect of negative g on circulation is
Answer
C. Ecchymoses around eyes
54
The following are true for denervated Heart Graft except
Answer
C. Decreased sensitivity to catecholamines
55
Positive feed back mechanism is seen in all except
Answer
C. Increased release of acid in stomach stimulate gastrin secretion
56
Which of the following is the correct statement about ventilation/perfusion ratio of lung ?
Answer
B. Normal value does not mean that ventilation and perfusion to that lung unit is normal
57
Which statement is incorrect about Pulmonary Surfactant ?
Answer
A. It is a complex mixture of proteins, carbohydrates and lipids
58
Which of the following statements is/are correct about pulmonary function values ? I. FRC is also known as relaxation volume II. Dead space and residual volume are functionally same III. Closing volume is the volume at which airways in the lower dependant parts of lung begin to close IV. Residual volume is the volume of air remaining in the lung after a normal expiration
Answer
A. I and III are correct
59
All the following statements about alveolar gas exchange is correct except
Answer
D. Diļ¬using capacity of is less than that of
60
Regarding chemical regulation of respiration which is correct ?
Answer
B. In denervation of carotid bodies ventilatory response to arterial is aļ¬ected by 30 to 35% only
61
Which of the following is not correct about Oxyhemoglobin Dissociation curve ?
Answer
C. The Hb saturation at a partial pressure of 50 mmHg is known as
62
Which one is correctly matched ? a) Anemic hypoxia e) Respiratory centre depression b) Hyoxic hyoxia f) Cyanotic congenital heart disease c) Stagnant hypoxia g) cyanide poisoning d) Histotoxic hypoxia h) Congestive cardiac failure i) Sulļ¬de poisoning j) CO poisoning
Answer
C. (c) and (h)
63
Which of the following statements about debt after severe exercise is/are true ? I. This will last for about 90 minutes II. The stimulus to increased ventilation during this period is increased and decreased III. Elevated arterial H+ ion concentration due to lactic acidosis causes increased ventilation IV. ATP and phosphoryl creatin resynthesis also occur during this time
Answer
D. I, III and IV are correct
64
Which is true about Narcosis ?
Answer
C. Alteration of ion conductance due to dissolved in membrane lipids produces symptoms
65
Which statement is false about Chloride shift ?
Answer
D. Increases haematocrit of venous blood by 0.5% as compared to arterial blood
66
Which statement is true about enteric nervous system ?
Answer
C. Intact autonomic innervation is not essential for its function
67
Which one is correctly matched ? a) Gastrin e) First discovered hormone b) Secretin f) Trophic action on gastric mucosa c) CCK g) Stimulation of gastric acid and pepsin secretion d) Somatostatin h) Inhibits secretion of gastrin i) Causes contraction of smooth muscles of stomach and intestine between meals
Answer
B. (d) and (h)
68
Which of the following increases concentration of urine ?
Answer
A. High protein diet
69
Which of the given factors do not increase renin secretion ? 1. Psychological stimuli 2. Prostaglandins 3. Diuretics 4. Hypernatremia
Answer
C. 4 Only
70
The main mechanism that stimulates sweat glands during exercise is
Answer
D. Circulating Catecholamines
71
Which hormone secretion is not under the regulation of positive feedback mechanism ?
Answer
C. Vasopressin
72
The process of sex diļ¬erentiation starts from which week of intrauterine life
Answer
B. Sixth week
73
A tuberculosis patient brought to the casualty with muscle cramps and nausea. Lab results show Plasma sodium concentration of 115 meq/l, serum osmolarity of 150 mosmol/kg, urine osmolarity of 2000 mosmo/kg, urine sodium of 500 meq/day and a normal blood volume. These clinical ļ¬ndings are consistent with which of the following ?
Answer
C. Increased secretion of Antidiuretic hormone
74
Which is not true regarding spermatogenesis ?
Answer
C. Teststerone secretion by Leydig cells is stimulated by FSH
75
A 50 yr old smoker complaints of the inability to smell. Which of the following is the most likely cause of anosmia ?
Answer
C. Metaplasia of the olfactory epithelium
76
Which tract is not involved in the regulation of posture ?
Answer
C. Rubrospinal tract
77
A 12 yr old boy with Duchenne muscular dystrophy has genetic mutation of the gene dystrophin. Dystrophin binds
Answer
D. Actin to Ī² dystroglycan
78
Nernst equation helps to calculate
Answer
A. Equilibrium potential for an ion
79
Cyclic GMP mediates the action of all except
Answer
D. EGF
80
A patient with Klinefelter syndrome presents with seminiferous tubule dysgenesis, Sertoli cells in the seminiferous tubules help in
Answer
B. Maintenance of blood testis barrier
81
Daily wage workers in a factory went on a hunger strike demanding hike in their salary. After three days of starvation, which of the following likely to manifest ?
Answer
C. Decreased gluconeogenesis
82
A young women diagnosed with anorexia nervosa presents with signiļ¬cant weight loss and a menorrhoea. Which of the following hormone cause development of ovarian follicles prior to ovulation ?
Answer
C. Follicle stimulating hormone
83
Which of the following is true about estrogen ?
Answer
B. Stimulate ductal proliferation in the breast
84
Which is true for sick euthyroid syndrome ?
Answer
B. Secretion of TSH is regulated primarily by the pituitary level of T3
85
Physiological changes that occur during pregnancy include
Answer
D. Reduced circulating gonadotrophin levels
86
After fertilization the day on which maternal HCG ļ¬rst appears in plasma ?
Answer
B. Sixth day
87
The geniculostriate ļ¬bres from lateral geniculate body form
Answer
B. Mangnocellular pathway that is concerned with detection of movement, depth, ļ¬icker
88
In Uppermotor neuron paralysis, spasticity occurs due to
Answer
B. Stimulation of reticulospinal tract
89
Which is true regarding Ankylosing spondylitis ?
Answer
C. Peak onset is 20 to 30 yrs
90
All are examples of regulated exocytosis except
Answer
B. Secretion of mucus from goblet cells
91
Which reļ¬ex is lost in decorticate animal ?
Answer
B. Placing and Hopping reaction
92
Which is not true about vestibular apparatus, when the head slowly rotates to right ?
Answer
C. The hair cells in the left horizontal semicircular canals become depolarized
93
Following are the features of Brown Sequard syndrome except
Answer
C. Paresis and spasticity of the muscles of the opposite side of the lesion
94
A 80 yr old man who develops septicaemia with multiorgan failure is on continuous hemodialysis. Which of the following will increase the diļ¬usive clearance of the solutes across the dialysis membrane ?
Answer
C. Increased area of the membrane
95
Hormone replacement therapy in postmenopausal women has the following eļ¬ects except
Answer
D. Increase the risk of osteoporosis
96
The main function of basal ganglia is
Answer
C. Planning and programming of movements
97
The hypothalamic areas present outside the blood brain barrier are except
Answer
C. Lateral preoptic area
98
A 70 yr old man is evaluated after a stroke found to suļ¬er from cerebellar lesions. He suļ¬ers from the following clinical features except
Answer
B. Paralysis
99
Which of the following best describes Turners syndrome ?
Answer
B. Horseshoe kidney frequently observed
100
Which is true about implantation of zygote in the uterine wall ?
Answer
C. Implantation occurs in the stage of blastocyst
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