| Post Name | BIO CHEMIST |
|---|---|
| Department | THE PHARMACEUTICAL CORPORATION(IM) KERALA Ltd |
| Question Paper Code | 189/2015 |
| Date of Test | 8 October 2015 |
| Medium of Question | ENGLISH |
| Exam Type | OMR Examination |
| Total Questions | 100 |
1
Which of the following intermediates of TCA cycle cannot de utilized for gluconeogenesis ?
Answer
D. Keto glutarate
2
Which statement best explains the function of the nuclear pore complex ?
Answer
D. It determines which proteins pass into and out of the nucleus
3
The function of cAMP in a cell is:
Answer
C. To activate kinases
4
The Nat -K* pump is:
Answer
B. An integral protein
5
Ifa protein contains a primary binding site and an allosteric site, what else can you predict
about this protein ?
Answer
A. Occupancy of the allosteric site alters the binding affinity of the primary site
6
Which of the following substance may not be useful in stabilizing enzyme solution ?
Answer
C. Nucleic acids
7
Which of the following best defines immunotoxins ¢
Answer
C. Toxins coupled to antigen-specific immunoglobulins
8
FSH secretion begins to rise and new follicles begin to zrow during ;
5 B a 5
Answer
A. The premenstrual phase
9
Construction of a restriction map of DNA requires all of the follawing except :
Answer
C. Cyclic heating and cooling of the reaction mixture
10
One theory of senescence is that it results from a lifetime of damage by :
Answer
C. Free radicals
11
The function of endonucleases during eukaryotic transcription termination is :
Answer
D. To cut the primary transcript RNA away from the RNA polymerase
12
All the following are constituents of ganglioside molecules except :
Answer
A. Glycerol
13
PS-I gets de-energised electrons from : |
Answer
C. Plastocyanin
14
One of them is a scientist involved in studies on vitamin D action :
Answer
A. Antony Norman
15
Which of the following statements explains the use of fluorochromes in immunophenoty ping
by clinical flow cytometry ?
Answer
B. All fluorochromes emit light at the same wavelength
16
What do flippases and floppases do ? 7
Answer
B. Move phospholipids from one face of a membrane to the other
17
Digestive enzymes are released by pancreas and bile is released by the liver in response to the
hormone :
Answer
C. Cholecystokinin
18
Membrane carriers resembles enzymes except for the fact that carners ;
Answer
C. Do not chemically change their ligands
19
Gibberellins stimulate :
Answer
D. Elongation of internode
20
Galactosemia is due to deficiency of :
Answer
D. All the above
21
Citrate is converted to isocitrate by aconitase which contains :
Answer
B. Fe²⁺
22
When the fiuid outside a cell has a greater concentration of a given molecule than the fluid
inside the cell, the external fluid is :
Answer
B. Hypertonic
23
eRF1 is release factor in eukaryotes that require :
Answer
B. GTP for its binding to ribosome
24
A molecule of CO, is captured by biotin when it acts as coenzyme for carboxylation reaction.
‘The carboxyl group is covalently attached to :
Answer
A. A nitrogen (Nj) of the biotin molecule
25
Which of the following cytokines plays a role in terminating inflammatory responses ?
Answer
C. TGF-p
26
During the formation of urine in the kidney, most of the water is reabsorbed into the blood in
the :
Answer
D. Proximal convoluted tubule
27
The following points about microfilaments are true except :
Answer
C. They form intracellular conducting channels
28
Production of more than one phenotypic trait by a single gene is called -
Answer
A. Pleiotrophy
29
Hydrolases are involved in hydrolysis of :
Answer
D. All the above
30
What are cadherins ?
Answer
A. Proteins that permit adjacent cells to form adherens junctions
31
The glial cells that destroy micro-organism in the CNS are :
Answer
A. Microglia
32
Which of the following does not contribute to the resolution attainable by a microscope ?
Answer
C. The magnification of the objective lens
33
Which of the following does not occur during PCR ?
Answer
A. Production of many pieces of single-stranded DNA
34
Tendons are compost of _ connective tissue.
|
Answer
C. Dense regular
35
Which event does not take place during anaphase A and/or anaphase B ?
Answer
A. Formation of kinetochore microtubules
36
A light chain gene is constructed from the following segments :
Answer
B. Variable, joining and constant segments
37
In the purine nucleus, carbon 6 is contributed by |
Answer
B. CO,
38
Some neurotransmitters can have either excitatory or inhibitory effects depending on the
type of :
Answer
A. Receptors on the postsynapiic neuron
39
A purely competitive inhibitor of an enzyme has which of the following, kinetics effects ?
Answer
A. Inereases Km without affecting Vmax
40
Which of the following is not a step taken to produce recombinant DNA using human DNA ?
Answer
B. Use retroviruses to circularize DNA
41
Oxamate is a competitive inhibitor of which of the following enzymes ?
Answer
C. Lactate dehydrogenase
42
Oxamate is a competitive inhibitor of which of the following enzymes
Answer
D. Pyruvate dehydrogenase
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43
A high ratio of insulin to glucagon can :
Answer
C. Occurs during fasting state
44
The ATP/AMP ratio has a major effect upon the rate of ATP production by glycolysis.
ATP and AMP bind to allosteric sites on:
Answer
C. Phosphofructokinase-1
45
The function of an adjuvant in a vaccine is :
Answer
D. Metabolism
46
Which of the following statements about dietary fiber is/are correct ?
Answer
A. Insoluble fiber increases stool bulk and decreases transit time
47
Creatine kinase is an: |
Answer
D. D) Isomerase |
48
Cholesterol inhibits estrogen action through its influence on :
Answer
C. nER I
49
One out of the following enzymes can utilize both NAD* and NADP* as a coenzyme :
Answer
D. Glycerol-3-P dehydrogenase
50
Excretion of conjugated bilirubin from liver cells into biliary canaliculi is defective in -
Answer
A. Gilbert's disease
51
Which signalling sequence uses both hydrocarbon and ions as second messengers ? |
Answer
D. RTK activation of MAP kinase
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52
Bf.
The genetic code that directs protein synthesis in human is found in :
Answer
B. No other kind of organism
53
What would be the consequence of defective ADH receptors ?
Answer
A. Diabetes mellitus
54
Which of the following is true ?
Answer
D. IgE binds phagocytes
55
Why can smooth muscle cells remain contracted for longer than striated muscle cells ?
Answer
A. They lack Z disc
56
The inner mitochondrial membrane is rich in which of the following phospholipids ?
Answer
B. Lecithin
57
The reason for the absence of testosterone in circulation in mammalian females is :
Answer
D. The entire testosterone produced get excreted
58
The carbon atom of urea is derived from :
Answer
D. Bicarbonate
59
In an individual at rest, who has fasted for 12 hours, which of the following occurs ?
Answer
B. Glycogen synthase 1s activated in liver
60
All are plant derived alkaloids except :
Answer
C. Codeine
61
Estrogen Receptor Activation Factor (E-RAF) is
Answer
B. Antiestrogen binding protein
62
One of the below is not modifiable risk factor for atherosclerosis :
Answer
C. Hypertension and lipid disorders
63
C, plants show very high rate of photosynthesis as compare to C, plants, because of :
Answer
D. All the above
64
All of the following are oncogenic except :
Answer
B. EB virus |
65
The glycosaminoglycan which does not contain uronic acid is :
Answer
B. Chondroitin sulphate
66
Organ of adhesion of bacteria is :
Answer
D. Flagella
67
Epinephrine increases the concentration of free fatty acids in plasma by increasing :
Answer
A. Extra mitochondrial fatty acid synthesis
68
Which of the following factors will affect the measurement of pH using a glass electrode ?
Answer
B. Valency of ions present
69
All are natural auxins except :
Answer
A. Indole acetic acid
70
Hukaryotes differ from prokaryotes in mechanism of DNA replication due to :
Answer
C. Use of DNA primer rather than RNA primer
71
The substance most likely to cause a rapid drop in blood pressure is :
Answer
B. Serotonin
72
The translocation of Ca2+ across a membrane involve all of the following except :
Answer
D. Active transport by Ca** — transporting ATPase
73
All of the following represent control of a metabolic process by substrate av ailability
except : ati
Answer
A. Rate of ketogenesis
74
F factor integrates with bacterial chromosome to form :
Answer
A. HFr
75
The surface tension in intestinal lumen between fat droplets and aqueous medium is
decreased by :
Answer
C. Cone. H,SO,
76
The immunoglobulin with the longest serum half-life is ;
Answer
B. IgM
77
All of the following contribute to the large, negative, free-energy change upon hydrolysis of
“high energy” compounds except -
;
Answer
B. Low activation energy of forward reaction
78
Choose the incorrect statement about Amino Acid Gl ycine :
Answer
D. Both glucogenic as well as ketogenic
79
Which of the membrane molecules are involved in antigen recognition and T cell
activation 7?
Answer
D. All of the above
80
The media for cultivation of anaerobic organism is :
Answer
B. Robertson's cooked meat broth
81
“Ente Jeevitha Samarangal” is the autobiography of ,
Answer
C. Mannathu Padmanabhan
82
§2. A foreigner to become the INC President twice -
Answer
D. William Wedderburn
83
§3. Black hole of Podanoor is related to : |
Answer
A. Mappila Lahala
84
How many ways by which a person can acquire Indian citizenship ?
Answer
C. c) 5
85
Article 280 deals with: ;
Answer
D. Planning Commission
86
The Headquarters of “Prathyaksha Raksha Daiva Sabha” (PRDS) loca ted in which district ?
Answer
B. Pathanamthitta
87
Who wrote “Aatmopadesa Sathakam” ?
Answer
C. Sree Narayana Guru
88
[S Indian Blind Women to won Indian Civil Services examination - 2015 :
Answer
B. Beno Seffin
89
Who won first Vayalar Award ?
Answer
A. Lalithambika Antharjanam
90
In which day is observed as the International Friendship day ?
Answer
B. July 30
91
Govt. of India recently launched a scheme called USTAAD to whom does it benefit t
Answer
C. Traditional Artisans
92
According to the World Happiness Report India was ranked _ among 157
countries and the happiest countries were Switzerland, Iceland, Denmark, Norway anc
Canada.
Answer
A. 117
93
Right to Education man dates all private unaided schools admit at least _ _ % of
their students in their entry-level class from socially disadvantaged and economically weaker
group.
Answer
B. 15
94
Who was the volunteer captain of Guruvayoor Sathyagraha ?
Answer
B. A.K. Gopalan
95
The Prefix ‘Mahakavi’ awarded to kumaranasan from Madras University in the year -
Answer
A. 1922
96
The most important property of nanomaterials is _ a
Answer
B. Friction
97
Which is the largest democracy of the world ?
Answer
C. India
98
| ___ Government has launched India’s First E - ration card service.
Answer
B. Delhi
99
Present Chief Information Commissioner of India ;
Answer
C. Vijay Sharma
100
Who is known as the “Jhansi rani of Kerala” ?
Answer
D. K.R. Gown Amma
-o0o-
189 / 2015 14 A
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