| Post Name | Research Officer- Chemistry/ Biochemistry |
|---|---|
| Department | Ayurveda Medical Education Drugs Standardisation Unit Category No :130/2020 |
| Question Paper Code | 027/2023/OL |
| Category Code | 130/2020 |
| Date of Test | 28 April 2023 |
| Exam Type | Online Examination |
| Total Questions | 100 |
1
Which of the following pair is correct about solubilizers and the bond they disrupt?
Answer
B. Urea - hydrogen bond, SDS - hydrophobic interaction, β - mercaptoethanol - disulpide bridges
2
Which among the following substituents enhance fluorescence of a compound? (i) -OH (ii) (iv) -COOH
Answer
A. (i) and (iii)
3
Nuclei that do not have possess spin property includes (i) (ii) (iii) (iv)
Answer
C. (i) and (iv)
4
Give the right sequence of RT-PCR (i) Taq polymerase extends target sequences (ii) Extract poly(A)+RNA (iii) Oligo primers bind to target sequences (iv) Extend with reverse transcriptase to form cDNA (v) ds cDNA denaturated by heating to >94°C (vi) Anneal Poly(dT) primer
Answer
A. (ii), (vi), (iv), (v), (iii), (i)
5
Which of the following is true for achromat objective lenses in a microscope? (i) They are cheapest objective lens (ii) They are corrected for spherical aberrations with green light (iii) They are best used when the light source utilizes a green filter and images are collected in grayscale (iv) They are spherically corrected for three wavelengths
Answer
D. (i), (ii), (iii)
6
Select the correct pair of luminescence system and measured moiety.
Answer
C. Firefly luminescence-ATP, bacterial luminescence-NADH, Chemiluminescence-
7
Choose the right facts in Connection to PAGE
Answer
B. Stacking gel has 2-3% acylamide and pH 6.7, Running gel has 5-10% acrylamide and pH 8.3
8
Match the following:
Answer
A. i-4, ii-3, iii-2, iv-1
9
Select the group consisting of compounds belonging to alkaloid class
Answer
A. Quinine, papaverine, nicotine, cocaine
10
Which of the following is true about function of alkaloids? i. Reserpine which lowers blood pressure ii. Cocaine is an anaesthetic iii. Vincristine is cytotoxic agents iv. Anthocyanins play an important role in insect mimicry
Answer
C. i, ii, iii
11
Which of the following does not belong to the class of phenolic compound?
Answer
D. Caffein
12
From which among the following is etoposide derived from?
Answer
B. Podophyllotoxin
13
Choose the set of secondary metabolites.
Answer
C. Malaxin, quercetin, Napthoquinones
14
____________ is the secondary metabolite obtained from 'tree of joy'.
Answer
B. Camptothecin
15
The techniques that help to determine functional group present in isolated secondary metabolite of a plant is
Answer
A. IR Spectroscopy
16
Choose the correct test to detect the presence of glycosides in plant extract.
Answer
A. Keller Killiani test
17
On shaking plant extract with acidified chloroform and allowing to stand, yellow colour appears in lower layer. Presence of which phytochemical is indicated by this test?
Answer
C. Triterpenoids
18
An enzyme with nomenclature EC 2.7.3.2 belongs to ___________ class.
Answer
A. Transferase
19
The sets of enzymes that are markers of myocardial infarction
Answer
D. GOT, CK, LDH
20
Which of the following statement is correct?
Answer
B. In Competitive inhibition Vmax is unchanged, Km increases
21
Bell shaped curve is obtained for enzyme velocity with
Answer
B. Increasing temperature and increasing pH
22
Select the false statement regarding active site of enzyme.
Answer
C. Active site is rigid in structure and shape
23
Km value is unchanged while Vmax is lowered in
Answer
B. Non-competitive inhibition
24
Which of the following is different from rest of the inhibitors?
Answer
Question Cancelled
25
Choose the correct pair of coenzyme and corresponding vitamin.
Answer
A. Vit B1-TPP, Vit B2-FMN, Vit B6-PLP
26
For plot of V against [S], allosteric enzyme exhibits
Answer
B. Sigmoidal curve
27
Acute pancreatitis is characterised by
Answer
B. ↑ Serum amylase
28
Choose the incorrect statement.
Answer
D. SEM has higher resolution than TEM
29
Bragg equation states that
Answer
C. nλ = 2dSinθ
30
Pick out the right statement regarding MALDI-TOF MS.
Answer
Question Cancelled
31
Mammalian cells use several cdks and cyclins to regulate passage through the cell cycle. Match the correct combinations which regulate the different phases of the cell cycle. Cdks Cyclins Cell cycle phases 1. Cdk1 a. Cycline A i. G1 phase 2. Cdk2 b. Cycline B ii. S phase 3. Cdk4 c. Cycline D iii. G2 phase iv. Mphase
Answer
A. 3. Cdk4 c. Cycline D i. G1 phase 2. Cdk2 a. Cycline A ii. S phase 1. Cdk1 b. Cycline A iii. G2 phase 1. Cdk1 a. Cycline B iv. M phase
32
The following are the molecular cancer biomarkers used to diagnose cancer in the human body. Find the correct combination of markers used to identify the different types of cancer A. AFP i. Brest cancer B. HER-2 ii. Colorectal cancer C. CA -125 iii. Liver cancer D. CEA iv. Ovarian cancer
Answer
C. A-iii, B-i, C-iv, D-ii
33
Movement of through open voltage-gated channels is driven by
Answer
D. The concentration gradient across the membrane and membrane potential at the peak of the action potential
34
Select the incorrect statements concerning membrane proteins A. The plasma membrane of the cell contains 50% of the proteins by mass B. The transmembrane proteins are amphipathic and can function on both sides of the bilayer or transport molecules across it C. Mutation (V509A) in integral membrane protein thyrotropin receptor leads to congential hypothyrodism D. Peripheral membrane proteins are permanently attached to one face of a membrane by noncovalent interactions with other membrane proteins and involve in cell signalling
Answer
D. C and D
35
The statements below address receptor-mediated endocytosis. Which of the following statements about receptor-mediated endocytosis is true? A. In receptor-mediated endocytosis, the extracellular materials bind to complementary receptors on the cell surface and enter the cell B. GGA adaptor molecule associated with clathrin-mediated endocytosis C. Receptor-mediated endocytoasis (RME) leads to the formation of mannose- coated pits D. Dynamin is a large GTP-binding accessory protein that aids in the release of the clathrin-coated vesicle from the membrane
Answer
B. A and D are true
36
Which of the following describes the effective dose of the drug?
Answer
C. The dose at which 50% of the tested animals exhibit a biological response
37
Match the following drugs with their General targets Drugs General Targets A. Rifampicin i. Act on 30S subunit of ribosome and block the protein synthesis B. Tetracycline ii. Binds to RNA polymerase and interferes transcription process C. Cephalosporins iii. Act on 50S subunit of ribosome and block the protein synthesis D. Erythromycin iv. Inhibit the cell wall synthesis
Answer
B. A-ii, B-i, C-iv, D-iii
38
Which of the following statement about Cytochrome P450 is false?
Answer
B. A fat-free diet increases the Cytochrome P450 level
39
Which of the following reaction doesn't involve phase II of drug metabolism
Answer
D. Hydroxylation
40
Match the bacterial toxins with their mode of action Toxins Mode of action A. Pertussis toxin i. Inhibit neurotransmitter release in a neuron B. Diphtheria toxin ii. Selective blockers of acetylcholine release from nerve endings C. Botulinum toxin iii. Inactivates elongation factor (EF-2) and inhibits protein synthesis D. Tetanus Toxin iv. Inactivities G proteins and blocks the signal transduction
Answer
A. A-iv, B-iii, C-ii, D-i
41
Hypersensitivity reactions can be classified into four types. Which of the following types has correctly matched concerning its immune responses? A. Type I - IgE mediated immediate reaction B. Type II - Immune complex-mediated reaction C. Type III - Antibody-mediated cytotoxic reaction (IgG or IgM antibodies) D. Type IV - Cell-mediated, delayed hypersensitivity reaction
Answer
C. A and D only
42
Which of the following statement is false with respect to type III Hypersensitivity reaction
Answer
B. Penicillin can induce Type III hypersensitivity reaction alone
43
Which of the following statements are not true about drug addiction? A. Drugs of abuse cause the brain's limbic system to release dopamine, the neurotransmitter that produces feelings of pleasure B. Drug tolerance makes people need more and more of the same drug because, over time, drugs will cause the brain to produce less dopamine C. Marijuana and heroin can activate neurons because their chemical structure mimics that of a natural neurotransmitter in the body D. Cocaine and amphetamines directly increase extracellular dopamine by blocking the presynaptic dopamine transporter (DAT)
Answer
D. None of the above
44
Classify the drug based on its source A. Digoxin i. Microbial B. Thyroxin ii. Synthetic C. Dextran iii. Plant D. Aspirin iv. Animal
Answer
B. A-iii, B-iv, C-i, D-ii
45
Drug distribution will be influenced by A. Tissue/organ blood flow B. Physicochemical properties of the drug C. Influx and efflux transporters D. Plasma protein and tissue binding
Answer
C. All of the above
46
The complement system is a potent mediator of inflammation and destruction and could cause extensive damage to host cells if uncontrolled. The complement system is tightly regulated by inhibitory/regulatory proteins. The following is the list of the key regulatory proteins that regulate the complement system. Match the regulatory proteins of the complement system with the stated functions. A. CI Inhibitor i. Enzymatically inactivities C4b and C3b B. DAF ii. Promotes C3b and C4b inactivation C. MCP iii. Binds to C1r and Cls prevents further activation of C4 and C2 D. Factor I iv. Inactivates C3b and C4b
Answer
B. A-iii, B-iv, C-ii, D-i
47
Which of the following statements regarding the live attenuated vaccine is incorrect?
Answer
D. Live attenuated vaccine is stable at normal room temperature
48
Which of the following method is currently used to deduce the evolutionary relationship between bacteria?
Answer
C. 16S rRNA analysis
49
Multidrug resistance in bacteria may be generated by A. Horizontal gene transfer B. Mutations in the DNA C. Enzymatic Inactivation of the Drug D. Increased expression of genes that code for multidrug efflux pumps
Answer
D. All of the above
50
The databases for the model organisms are given below. Match it to appropriate model organisms A. MAtDB i. Mouse B. FlyBase ii. C.elegans C. WormBase iii. Arabidopsis D. MGI iv. Drosophilia
Answer
A. A-iii, B-iv, C-ii, D-i
51
If the centre of gravity of a molecule changes during motion, then the molecule have,
Answer
B. Translational Energy
52
Identify the correct statement from the following A. Spectroscopy is the study of the interaction between matter and radiated energy B. Spectrometry is a practical measurement in the atomic and molecular balances of matter C. Spectroscopy is a theoretical method of science that does not produce any results D. Spectrometry the study of matter's absorption properties or absorption behaviour when exposed to electromagnetic radiation.
Answer
D. All statements are correct
53
When we consider Raman scattering spectrum, and if we designate the intensities of the most intense lines of the stoke lines, Anti stokes lines and Raleigh scattering are Iₐ, I_b and I_c respectively, the increasing order will be
Answer
D. I_c > Iₐ > I_b
54
Carbonyl group show somewhere in ultraviolet region, but their 2,4 dinitrophenylhydrazone derivatives show in the visible region. This is due to
Answer
B. Bathochromic shift
55
Select the false statement(s) from the following A. As bond order decreases, bond energy as well as force constant increase B. As bond energy increases, bond length decreases and force constant increases C. As bond length increases bond energy decreases and force constant also decreases D. As force constant decreases, bond length decreases and bond energy increases
Answer
B. A and D are false
56
The expected number of ESR signals for methyl free radical and benzen anion are respectively
Answer
B. 4 and 7
57
Which one of the following is false for Doppler broadening of spectral lines
Answer
D. Doppler broadening is proportional to pressure of the gas
58
Identify the statement regarding the reference molecule used in NMR spectrsocopy A. TMS will give weak NMR absorption even in dilute solutions B. The Shielding of protons in TMS is greater than in most organic molecules C. The methyl group of DSS resonate at a different position of the methyl group of TMS D. DSS or its sodium salt is more often used as calibration standard of NMR for protein experiments in water
Answer
D. D and B are correct
59
The transitions of the electron between the molecular orbitals for the absorption in the region 200 to 800 nm is not possible for
Answer
A. σ → σ*
60
Which of the following are the Quantum mechanics methods used in computational chemistry
Answer
B. Ab initio method and DFT
61
Which of the following statement(s) are correct A. Glass electrode only compares pH values while the hydrogen electrode measure pH absolutely B. The pH values measured by quinhydrone electrode are very accurate even in the presence of oxidising ions C. Potentiometry is a method of electroanalysis is used to find the concentration of a solute in a solution D. Amperometry is the technique to detect the ions in a solution depending on electric voltage or changes in redox potential
Answer
A. A, B and C are correct
62
The Electrokinetic phenomenon in which the movement of particles causes potential is
Answer
C. Streaming potential
63
Which of the following is not suitable for Amperometry?
Answer
B. Identification of polysaccharide
64
The salts of a given metal can be arranged in order of their decreasing ability to remove Iyophilic substances from colloidal solution. This series is called
Answer
A. Hofmeister series
65
Identify the correct statements A. During gelation there is a large increase in viscosity B. Imbibation pressure breaks the soil around the seeds during germination C. A small amount of electrolyte increases the zeta potential of Iyophilic colloids D. Critical Micellar concentration decreases as the molecular weight of a hydrocarbon chain increases
Answer
B. A, B and D are correct
66
Identify the correct statements(s) from the following A. Regioselectivity of the hydroboration step can be improved with bulky boranes B. For mono-substituted cyclohexane, the equatorial conformer is more stable than the axial-conformer because of the 1,3- diaxal interaction C. Hydroboration/Oxidation proceeds in an Anti-Markovnikov manner, where the hydrogen from or attaches to the more substituted carbon D. Addition of to a carbon carbon double bond is Markovinikov syn addition
Answer
C. A, B and C are correct
67
If we consider trans-1-t-butyl-3 methylcyclohexane, in its most stable conformation, then the substituents at C1 and C3 are
Answer
C. Equatorial and Axial positions respectively
68
Which one of the following could be grouped as prochiral molecules?
Answer
A. Pyruvic acid and propionic acid
69
Cyclopentadiene is more acidic than cyclopentane, because
Answer
C. Cyclopentadiene has conjugated double and once deprotonated, the orbitals on the carbon atom would re-hybridize from to placing the lone-pair of electrons in the new p-orbital making resulting the molecule aromatic
70
The mechanism of oxymercuration of an alkene to yield an alcohol follows
Answer
A. Electrophilic Addition Reaction
71
The alkaloid pilocarpine extracted from the leaves of pilocarpus microphyllus is an
Answer
C. Imidazole Alkaloid
72
In IR spectraum of para nitro phenyl acetate, Carbonyl absorption band may range on
Answer
B. 1760-1765
73
How many peaks could be expected in the proton decoupled NMR spectra of 1-methyl cyclohexene and methylcyclohexane respectively?
Answer
A. Seven and Five
74
Which one of the following group of compound belongs to Terpenes?
Answer
D. Caravone, Geraniol and Myrcene
75
What is the correct order of λ_max for n→π* transition for the following organic groups, R−N=N−R, R−CN and R−NO₂?
Answer
B. R−CN < R−NO₂ < R−N=N−R
76
Which among the following statements are correct? A. Ninhydrin is sprayed to locate amino acids and on applying ninhydrin amino acids will be appeared in pink to purple colour B. The four main system in HPLC are mobile phase reservoirs Injector system, column and detector C. Gas chromatography is a type of adsorption chromatography in which the mobile phase is a gas D. Elutropic series is a series of various compounds in order of adsorbtion power for a given adsorbent
Answer
C. A, B and C are correct
77
Which of the following set of reactions are given by citral?
Answer
D. React with bisulphite, Ozone and exhibit geometrical isomerism
78
During ion exchange separation, ion exchange is favoured at higher concentration, when
Answer
C. Resin has higher positive charge and solution has lower positive charge
79
Identify the wrong statement(s) from the following A. In GC-MS the compounds to be analysed must be sufficienly volatile and thermally stable B. The gas chromatograph utilises a capillary colomn which does not depend upon colomn's dimension as well as the phase properties C. Electrospray ionisation method in LC-MS can be used for highly polar, highly stable or thermally stable compounds D. Carrier gas used in GC-MS are nitrogen helium argon and Hydrogen
Answer
B. B and C are wrong
80
Crypton is a natural terpenoid which
Answer
D. Contains nine carbon atom and does not obey isoprene rule
81
Which among the following is the function of Chopper in AAS?
Answer
C. To convert steady light into pulsating light
82
A 7.25×10⁻⁵ M solution of potassium permanganate has a transmittance of 20% when measured in a 2.10 cm cell at a wavelength of 525 nm. The molar absorptivity of potassium permanganate solution is _____ L mol⁻¹ cm⁻¹.
Answer
B. 4.59×10⁻³
83
If DTA of is carried out in an inert atmosphere, the number of exothermic peaks are
Answer
A. 0
84
Statement I : SEM is least appropriate for small particles Statement II: Small nanoparticles contribute very little to the signal obtained by SEM. Find the correct option from the following
Answer
B. Statement I is correct and Statement II is the correct explanation for statement I
85
Which of the following is a greener route to produce ethanol commercially?
Answer
D. Oxidation of ethene with an ionic catalyst
86
The term Cryptand refers to
Answer
C. Macromolecules with nitrogen and oxygen donor
87
Which of the following is an anion receptor?
Answer
A. Carboxy peptidase A
88
Which enzyme regulates the external signal flapping in the molecular switches?
Answer
C. Kinase
89
Supramolecular Calixarenes contain
Answer
D. OH
90
Molecular Tweezers is primarily concerned with
Answer
B. Non covalent bond
91
Predict the correct order of magnetic moment for the following geometry pf Ni(II) complexes
Answer
A. Square planar < Octahedral < Tetrahedral
92
Which of the following statement is incorrect about Zeise's salt?
Answer
C. All the Pt-Cl bond length in Zeise's salt are not equal
93
Indicate the number of Mossbauer peaks in the spectrum of
Answer
D. 3
94
How many metal-metal bonds are present in ?
Answer
C. 3
95
Ferrocene cannot undergo which of the following reactions?
Answer
B. Diels-Alder reaction
96
The order of CO infrared stretching frequencies in Ni(CO)₄, Ni(CO)₃(PMe₃), Ni(CO)₂(PMe₃)₂ is
Answer
B. Ni(CO)₄ > Ni(CO)₃(PMe₃) > Ni(CO)₂(PMe₃)₂
97
The oxidation state of iron in methemoglobin is
Answer
C. Three
98
If ATPase pumps 6 out of the cell and 4 into the cell, the number of ATP consumed
Answer
B. 2
99
Identify the correct statement for the EPR spectrum of [with square pyramidal geometry at Vanadium ] at 77K [I value of ] A. It has two g values B. It has one g value C. It has 8 lines only D. It has 2 patterns of 8 lines
Answer
A. A and D
100
For the given complex , the coordination number and geometry respectively, are
Answer
C. 8 and hexagonal bipyramidal
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